PMID- 16181532
OWN - NLM
STAT- MEDLINE
DCOM- 20060119
LR  - 20191109
IS  - 1672-0415 (Print)
IS  - 1672-0415 (Linking)
VI  - 11
IP  - 3
DP  - 2005 Sep
TI  - [Effect of Astragalus injection on plasma levels of apoptosis-related factors in 
      aged patients with chronic heart failure].
PG  - 187-90
AB  - OBJECTIVE: To investigate the effect of Astragalus injection (AI) on plasma 
      levels of apoptosis-related factors in aged patients with chronic heart failure 
      (CHF). METHODS: Seventy-two CHF patients were randomly divided into the AI group 
      (36 cases) treated with AI and the control group (36 cases) treated with 
      conventional treatment. Plasma levels of soluble Fas (sFas), soluble Fas ligand 
      (sFasL), tumor necrosis factor alpha (TNF-alpha) and interleukin-6 (IL-6) were 
      measured by enzyme-linked immunosorbent assays (ELISA) with monoclonal anti-human 
      antibodies. Besides, New York Heart Association (NYHA) grading was assessed 
      according to improved symptoms and left ventricular end-diastolic volume (LVEDV), 
      left ventricular end-systolic volume (LVESV) and left ventricular ejection 
      fraction (LVEF) were assessed by echocardiogram after 4 weeks of treatment. 
      RESULTS: After 4 weeks of treatment, NYHA grading was markedly improved in the 
      two groups, but it was significantly better in AI group than that in the control 
      group (P < 0.05). As compared with the control group, sFas, sFasL, TNF-alpha and 
      IL-6 in the AI group were obviously lower, the difference between the two groups 
      and between before and after treatment were significant (P < 0.05 or P < 0.01). 
      Moreover, in AI group, LVESV and LVEDV decreased, LVEF increased, which was 
      significantly different than that before treatment (P < 0.05), respectively. 
      CONCLUSION: AI could lower plasma levels of apoptosis-related factors, and is one 
      of the effective drugs in improving cardiac function in the aged patients with 
      CHF.
FAU - Zhang, Jin-guo
AU  - Zhang JG
AD  - Department of Cardiology, Affiliated Hospital of Jining Medical College, Shandong 
      272029, China. jgzhang@183.ha.cn
FAU - Yang, Na
AU  - Yang N
FAU - He, Hua
AU  - He H
FAU - Wei, Guang-he
AU  - Wei GH
FAU - Gao, Dong-sheng
AU  - Gao DS
FAU - Wang, Xiao-li
AU  - Wang XL
FAU - Wang, Xue-zhong
AU  - Wang XZ
FAU - Song, Guang-yao
AU  - Song GY
LA  - chi
PT  - Journal Article
PT  - Randomized Controlled Trial
PL  - China
TA  - Chin J Integr Med
JT  - Chinese journal of integrative medicine
JID - 101181180
RN  - 0 (FASLG protein, human)
RN  - 0 (Fas Ligand Protein)
RN  - 0 (Interleukin-6)
RN  - 0 (Membrane Glycoproteins)
RN  - 0 (Plant Preparations)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 0 (Tumor Necrosis Factors)
RN  - 0 (fas Receptor)
SB  - IM
MH  - Age Factors
MH  - Aged
MH  - Apoptosis/immunology
MH  - *Astragalus Plant
MH  - Fas Ligand Protein
MH  - Female
MH  - Heart Failure/blood/*drug therapy/immunology
MH  - Humans
MH  - Injections
MH  - Interleukin-6/blood
MH  - Male
MH  - Membrane Glycoproteins/blood
MH  - Middle Aged
MH  - *Phytotherapy
MH  - Plant Preparations/*administration & dosage
MH  - Tumor Necrosis Factor-alpha/analysis
MH  - Tumor Necrosis Factors/blood
MH  - fas Receptor/blood
EDAT- 2005/09/27 09:00
MHDA- 2006/01/20 09:00
CRDT- 2005/09/27 09:00
PHST- 2005/09/27 09:00 [pubmed]
PHST- 2006/01/20 09:00 [medline]
PHST- 2005/09/27 09:00 [entrez]
AID - 10.1007/BF02836502 [doi]
PST - ppublish
SO  - Chin J Integr Med. 2005 Sep;11(3):187-90. doi: 10.1007/BF02836502.