PMID- 16181614
OWN - NLM
STAT- MEDLINE
DCOM- 20060404
LR  - 20240312
IS  - 0006-3223 (Print)
IS  - 0006-3223 (Linking)
VI  - 59
IP  - 4
DP  - 2006 Feb 15
TI  - Brain-derived neurotrophic factor and autoantibodies to neural antigens in sera 
      of children with autistic spectrum disorders, Landau-Kleffner syndrome, and 
      epilepsy.
PG  - 354-63
AB  - BACKGROUND: Brain derived neurotrophic factor (BDNF) elevation in newborn sera 
      predicts intellectual/social developmental abnormalities. Other autoantibodies 
      (AAs) to endothelial cells (ECs) and myelin basic protein (MBP) are also elevated 
      in some children. We tested relationships between BDNF, BDNF AAs, and other AAs 
      in children with these disorders. METHODS: BDNF levels and IgG/IgM autoantibodies 
      to BDNF, ECs, MBP, and histones were measured in children with autism, childhood 
      disintegrative disorder (CDD), pervasive developmental delay-not otherwise 
      specified (PDD-nos), acquired epilepsy, Landau-Kleffner syndrome (LKS); healthy 
      children (HC), and children with non-neurological illnesses (NNI). RESULTS: Mean 
      BDNF levels were elevated in children with autism and CDD, (p < or = 0.0002) 
      compared to HC or NNI. Mean IgG and IgM BDNF AAs were elevated in children with 
      autism, CDD and epilepsy (p < or = 0.0005) compared to HC but not to NNI. Mean 
      IgM AA EC titers detected by immunocytochemistry were higher in autism, PDD-NOS, 
      epilepsy, and LKS (p < or = 0.005) compared to HC and NNI. While mean ELISA IgG 
      EC AAs were higher in autism and PPD-NOS (p < 0.005) compared to HC but not NNI, 
      ELISA IgM EC AAs were higher in children with autism, CDD, PDD-NOS, and epilepsy 
      compared to both HC and NNI (p < 0.0005). Mean anti-MBP IgG and IgM titers were 
      higher in all study groups (p < 0.005) except for LKS compared to both HC and 
      NNI. CONCLUSION: Children with developmental disorders and epilepsy have higher 
      AAs to several neural antigens compared to controls. The presence of both BDNF 
      AAs and elevated BDNF levels in some children with autism and CDD suggests a 
      previously unrecognized interaction between the immune system and BDNF.
FAU - Connolly, Anne M
AU  - Connolly AM
AD  - Department of Neurology and Pediatrics, Washington University School of Medicine, 
      St. Louis, Missouri 63110, USA.
FAU - Chez, Michael
AU  - Chez M
FAU - Streif, Elizabeth M
AU  - Streif EM
FAU - Keeling, Richard M
AU  - Keeling RM
FAU - Golumbek, Paul T
AU  - Golumbek PT
FAU - Kwon, Jennifer M
AU  - Kwon JM
FAU - Riviello, James J
AU  - Riviello JJ
FAU - Robinson, Ricki G
AU  - Robinson RG
FAU - Neuman, Rosalind J
AU  - Neuman RJ
FAU - Deuel, Ruth Mary K
AU  - Deuel RM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20050921
PL  - United States
TA  - Biol Psychiatry
JT  - Biological psychiatry
JID - 0213264
RN  - 0 (Antibodies, Antinuclear)
RN  - 0 (Autoantibodies)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Histones)
RN  - 0 (Immunoglobulin G)
RN  - 0 (Immunoglobulin M)
RN  - 0 (Myelin Basic Protein)
SB  - IM
MH  - Antibodies, Antinuclear/analysis
MH  - Autistic Disorder/*immunology/*metabolism
MH  - Autoantibodies/analysis/*immunology
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Cells, Cultured
MH  - Cerebral Cortex/immunology/metabolism
MH  - Child
MH  - Child, Preschool
MH  - Cohort Studies
MH  - Endothelial Cells/metabolism
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Epilepsy/*immunology
MH  - Female
MH  - Histones/immunology/metabolism
MH  - Humans
MH  - Immunoglobulin G/analysis/immunology
MH  - Immunoglobulin M/analysis/immunology
MH  - Immunohistochemistry
MH  - Landau-Kleffner Syndrome/*immunology/*metabolism
MH  - Male
MH  - Myelin Basic Protein/immunology/metabolism
MH  - Nervous System/*immunology/*metabolism
MH  - Umbilical Veins/cytology
EDAT- 2005/09/27 09:00
MHDA- 2006/04/06 09:00
CRDT- 2005/09/27 09:00
PHST- 2005/01/19 00:00 [received]
PHST- 2005/06/10 00:00 [revised]
PHST- 2005/07/01 00:00 [accepted]
PHST- 2005/09/27 09:00 [pubmed]
PHST- 2006/04/06 09:00 [medline]
PHST- 2005/09/27 09:00 [entrez]
AID - S0006-3223(05)00851-6 [pii]
AID - 10.1016/j.biopsych.2005.07.004 [doi]
PST - ppublish
SO  - Biol Psychiatry. 2006 Feb 15;59(4):354-63. doi: 10.1016/j.biopsych.2005.07.004. 
      Epub 2005 Sep 21.