PMID- 16181861
OWN - NLM
STAT- MEDLINE
DCOM- 20060919
LR  - 20191210
IS  - 1552-6259 (Electronic)
IS  - 0003-4975 (Linking)
VI  - 80
IP  - 4
DP  - 2005 Oct
TI  - Edge-to-edge repair with mitral annuloplasty for Barlow's disease.
PG  - 1315-8
AB  - BACKGROUND: The purpose of this study was to define the early and midterm results 
      obtained after the use of edge-to-edge repair with mitral annuloplasty in the 
      setting of Barlow's disease. METHODS: Between 1998 and 2004, 41 patients having 
      Barlow's disease had an edge-to-edge repair creating a double-lumen mitral valve 
      orifice in our unit. In 38 patients (93%), an annuloplasty band was also 
      inserted. RESULTS: Preoperatively, all patients had severe mitral regurgitation 
      (MR), 12 were in New York Heart Association (NYHA) class I, 15 in class II, and 
      14 in class III. One patient died in hospital (2.4%) and 5 experienced 
      complications (12.5%). There were no late deaths. At follow-up, 2 patients had 
      severe MR and underwent valve replacement, 1 exhibited moderate MR, and 5 had 
      mild MR. Kaplan-Meier 5-year survival, freedom from reoperation and recurrent 
      moderate-severe MR was 97.6% +/- 2.4%, 94% +/- 4.4%, and 90.6% +/- 5.1%, 
      respectively. At latest echocardiographic evaluation (mean 35 +/- 12 months) the 
      mean left ventricular end-systolic and end-diastolic diameters, and the mitral 
      valve area decreased (p = 0.0001) compared with baseline. The mean mitral valve 
      gradient increased (p = 0.001) without clinical evidence of mitral stenosis 
      whereas ejection fraction did not change. Currently, 35 patients are in NYHA 
      class I and 5 are in class II. CONCLUSIONS: In the setting of Barlow's disease, 
      use of edge-to-edge repair with mitral annuloplasty is safe and provides lasting 
      restoration of mitral valve competence with measurable hemodynamic and clinical 
      benefits. In our unit, it is the procedure of choice for correction of MR in 
      patients having Barlow's disease.
FAU - Oc, Mehmet
AU  - Oc M
AD  - Department of Cardiac Surgery, Glenfield Hospital, University of Leicester, 
      Leicester, United Kingdom.
FAU - Doukas, George
AU  - Doukas G
FAU - Alexiou, Christos
AU  - Alexiou C
FAU - Oc, Bahar
AU  - Oc B
FAU - Hadjinikolaou, Leon
AU  - Hadjinikolaou L
FAU - Sosnowski, Andrzej W
AU  - Sosnowski AW
FAU - Spyt, Tomasz J
AU  - Spyt TJ
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PL  - Netherlands
TA  - Ann Thorac Surg
JT  - The Annals of thoracic surgery
JID - 15030100R
SB  - IM
MH  - Aged
MH  - Cardiac Surgical Procedures/methods/statistics & numerical data
MH  - Echocardiography
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Mitral Valve Insufficiency/diagnosis/diagnostic imaging/*surgery
MH  - Outcome and Process Assessment, Health Care
MH  - Reoperation/statistics & numerical data
MH  - Survival Analysis
MH  - Treatment Outcome
EDAT- 2005/09/27 09:00
MHDA- 2006/09/20 09:00
CRDT- 2005/09/27 09:00
PHST- 2004/11/26 00:00 [received]
PHST- 2005/02/25 00:00 [revised]
PHST- 2005/03/04 00:00 [accepted]
PHST- 2005/09/27 09:00 [pubmed]
PHST- 2006/09/20 09:00 [medline]
PHST- 2005/09/27 09:00 [entrez]
AID - S0003-4975(05)00379-6 [pii]
AID - 10.1016/j.athoracsur.2005.03.022 [doi]
PST - ppublish
SO  - Ann Thorac Surg. 2005 Oct;80(4):1315-8. doi: 10.1016/j.athoracsur.2005.03.022.