PMID- 16182262
OWN - NLM
STAT- MEDLINE
DCOM- 20060224
LR  - 20221207
IS  - 0006-8993 (Print)
IS  - 0006-8993 (Linking)
VI  - 1059
IP  - 1
DP  - 2005 Oct 12
TI  - Altered depression-related behavior and neurochemical changes in serotonergic 
      neurons in mutant R406W human tau transgenic mice.
PG  - 7-12
AB  - Mutant R406W human tau was originally identified in frontotemporal dementia and 
      parkinsonism linked to chromosome 17 (FTDP-17) and causes a hereditary tauopathy 
      that clinically resembles Alzheimer's disease (AD). In the current study, we 
      examined the performance of R406W transgenic (Tg) mice in the forced swimming 
      test, a test with high predictivity of antidepressant efficacy in human 
      depression, and found an enhancement of the immobility time. In contrast, the 
      motor function and anxiety-related emotional response of R406W Tg mice were 
      normal. Furthermore, a selective serotonin reuptake inhibitor (SSRI), fluvoxamine 
      (100 mg/kg, p.o.), significantly reduced this enhancement of the immobility time, 
      whereas a noradrenaline reuptake inhibitor, desipramine, had no effect. In an in 
      vivo microdialysis study, R406W Tg mice exhibited a significantly decreased 
      extracellular 5-hydroxyindoleacetic acid (5-HIAA) level in the frontal cortex and 
      also exhibited a tendency toward a decreased extracellular 5-hydroxytryptamine 
      (5-HT) level. Moreover, fluvoxamine, which reduced the enhancement of the 
      immobility time, significantly increased the extracellular 5-HT level in R406W Tg 
      mice. These results suggest that R406W Tg mice exhibit changes in 
      depression-related behavior involving serotonergic neurons and provide an animal 
      model for investigating AD with depression.
FAU - Egashira, Nobuaki
AU  - Egashira N
AD  - Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka 
      University, 8-19-1 Nanakuma, Fukuoka 814-0180, Japan.
FAU - Iwasaki, Katsunori
AU  - Iwasaki K
FAU - Takashima, Akihiko
AU  - Takashima A
FAU - Watanabe, Takuya
AU  - Watanabe T
FAU - Kawabe, Hideyuki
AU  - Kawabe H
FAU - Matsuda, Tomomi
AU  - Matsuda T
FAU - Mishima, Kenichi
AU  - Mishima K
FAU - Chidori, Shozo
AU  - Chidori S
FAU - Nishimura, Ryoji
AU  - Nishimura R
FAU - Fujiwara, Michihiro
AU  - Fujiwara M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20050921
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
RN  - 0 (Serotonin Uptake Inhibitors)
RN  - 0 (tau Proteins)
RN  - 333DO1RDJY (Serotonin)
RN  - 54-16-0 (Hydroxyindoleacetic Acid)
RN  - O4L1XPO44W (Fluvoxamine)
SB  - IM
MH  - Alzheimer Disease/*complications/genetics/psychology
MH  - Animals
MH  - Behavior, Animal/physiology
MH  - Brain Chemistry/genetics
MH  - Depressive Disorder/*genetics/physiopathology/psychology
MH  - Disease Models, Animal
MH  - Extracellular Fluid/metabolism
MH  - Fluvoxamine/pharmacology
MH  - Humans
MH  - Hydroxyindoleacetic Acid/metabolism
MH  - Mice
MH  - Mice, Transgenic
MH  - Microdialysis
MH  - Motor Activity/genetics
MH  - Mutation/*genetics
MH  - Neurons/*metabolism
MH  - Raphe Nuclei/*metabolism
MH  - Serotonin/metabolism
MH  - Selective Serotonin Reuptake Inhibitors/pharmacology
MH  - Swimming/psychology
MH  - Up-Regulation/drug effects/genetics
MH  - tau Proteins/*genetics
EDAT- 2005/09/27 09:00
MHDA- 2006/02/25 09:00
CRDT- 2005/09/27 09:00
PHST- 2005/04/15 00:00 [received]
PHST- 2005/08/02 00:00 [revised]
PHST- 2005/08/05 00:00 [accepted]
PHST- 2005/09/27 09:00 [pubmed]
PHST- 2006/02/25 09:00 [medline]
PHST- 2005/09/27 09:00 [entrez]
AID - S0006-8993(05)01170-4 [pii]
AID - 10.1016/j.brainres.2005.08.004 [doi]
PST - ppublish
SO  - Brain Res. 2005 Oct 12;1059(1):7-12. doi: 10.1016/j.brainres.2005.08.004. Epub 
      2005 Sep 21.