PMID- 16182380
OWN - NLM
STAT- MEDLINE
DCOM- 20060125
LR  - 20061115
IS  - 0165-5728 (Print)
IS  - 0165-5728 (Linking)
VI  - 169
IP  - 1-2
DP  - 2005 Dec
TI  - Dynamics of monocyte chemoattractant protein type one (MCP-1) and HIV viral load 
      in human cerebrospinal fluid and plasma.
PG  - 144-52
AB  - BACKGROUND: Increased expression of monocyte chemoattractant protein type 1 
      (MCP-1) is associated with HIV CNS disease. This study evaluated the temporal 
      relationships between MCP-1 expression and HIV replication in the CNS. METHODS: 
      MCP-1 and HIV viral load (VL) were measured in serially obtained samples of 
      plasma and cerebrospinal fluid (CSF) in subjects either interrupting (TI) or 
      starting (TS) antiretroviral therapy. RESULTS: Following TI, plasma VL rebounded 
      first, followed by increases in CSF MCP-1, which immediately preceded or 
      coincided with a rebound of CSF VL. CONCLUSION: The close temporal relationship 
      of the increase of MCP-1 and CSF VL suggests that they are co-regulated, or that 
      one is a stimulus for the other.
FAU - Monteiro de Almeida, Sergio
AU  - Monteiro de Almeida S
AD  - HIV Neurobehavioral Research Center, UCSD, 150 West Washington St., 2nd Flr., San 
      Diego, CA 92103, USA.
FAU - Letendre, Scott
AU  - Letendre S
FAU - Zimmerman, Joshua
AU  - Zimmerman J
FAU - Lazzaretto, Deborah
AU  - Lazzaretto D
FAU - McCutchan, Allen
AU  - McCutchan A
FAU - Ellis, Ronald
AU  - Ellis R
LA  - eng
PT  - Clinical Trial
PT  - Comparative Study
PT  - Journal Article
DEP - 20050922
PL  - Netherlands
TA  - J Neuroimmunol
JT  - Journal of neuroimmunology
JID - 8109498
RN  - 0 (Anti-Retroviral Agents)
RN  - 0 (Chemokine CCL2)
RN  - 0 (RNA, Viral)
SB  - IM
MH  - Anti-Retroviral Agents/therapeutic use
MH  - Chemokine CCL2/*blood/*cerebrospinal fluid
MH  - Cognition Disorders/etiology/virology
MH  - Female
MH  - HIV Infections/*blood/*cerebrospinal fluid/complications/drug therapy
MH  - HIV-1/drug effects/genetics/*isolation & purification
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - RNA, Viral/blood/cerebrospinal fluid
MH  - Time Factors
MH  - Viral Load/methods
EDAT- 2005/09/27 09:00
MHDA- 2006/01/26 09:00
CRDT- 2005/09/27 09:00
PHST- 2004/07/20 00:00 [received]
PHST- 2005/07/18 00:00 [revised]
PHST- 2005/07/20 00:00 [accepted]
PHST- 2005/09/27 09:00 [pubmed]
PHST- 2006/01/26 09:00 [medline]
PHST- 2005/09/27 09:00 [entrez]
AID - S0165-5728(05)00317-6 [pii]
AID - 10.1016/j.jneuroim.2005.07.012 [doi]
PST - ppublish
SO  - J Neuroimmunol. 2005 Dec;169(1-2):144-52. doi: 10.1016/j.jneuroim.2005.07.012. 
      Epub 2005 Sep 22.