PMID- 16184349
OWN - NLM
STAT- MEDLINE
DCOM- 20060314
LR  - 20181113
IS  - 0340-1855 (Print)
IS  - 0340-1855 (Linking)
VI  - 64
IP  - 6
DP  - 2005 Sep
TI  - [Research strategies towards a holistic characterization of rheumatoid 
      arthritis--a systems biology approach].
PG  - 408-15
AB  - Genome-wide screening methods used in functional genomics (genome, transcriptome, 
      proteome and metabolom analysis) have increasingly been conducted in integrative 
      research platforms to enable a comprehensive holistic characterization of 
      multifactorial polygenic diseases. First results of this research strategy 
      demonstrate that extended data sets are compiled whose quality is ensured by the 
      application of standard operating procedures (SOPs) and the integration of 
      specific laboratory information management systems (LIMS). Experimental data 
      derived from this technology and methodology platform are obtained by applying 
      standardized sampling procedures followed by comprehensive experimental 
      validation and bioinformatic comparisons with the world knowledge publicly 
      available. This research strategy should finally lead to a holistic understanding 
      of the pathogenesis presented in rheumatoid arthritis by identifying 
      disease-associated regulatory networks (pathways) and assigning them to cell 
      populations involved in the disease mechanisms. In addition, it has to be 
      investigated to what extent genetic as well as epigenetic factors direct disease 
      initiation and progression in potential conjunction with environmental impacts 
      (infections, smoking, etc.).
FAU - Thiel, A
AU  - Thiel A
AD  - Deutsches Rheumaforschungszentrum, Berlin, Germany.
FAU - Thiesen, H-J
AU  - Thiesen HJ
LA  - ger
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
TT  - Forschungsstrategien zur ganzheitlichen Charakterisierung der Rheumatoiden 
      Arthritis -- Ein systembiologischer Ansatz.
PL  - Germany
TA  - Z Rheumatol
JT  - Zeitschrift fur Rheumatologie
JID - 0414162
RN  - 0 (Cytokines)
SB  - IM
MH  - Animals
MH  - Arthritis, Rheumatoid/diagnosis/*physiopathology/therapy
MH  - Cytokines/*genetics/*immunology
MH  - Gene Expression Regulation/*immunology
MH  - Genomics/*methods/trends
MH  - Humans
MH  - Research/trends
MH  - *Research Design
MH  - Systems Biology/*methods/trends
RF  - 33
EDAT- 2005/09/27 09:00
MHDA- 2006/03/15 09:00
CRDT- 2005/09/27 09:00
PHST- 2005/07/12 00:00 [received]
PHST- 2005/07/28 00:00 [accepted]
PHST- 2005/09/27 09:00 [pubmed]
PHST- 2006/03/15 09:00 [medline]
PHST- 2005/09/27 09:00 [entrez]
AID - 10.1007/s00393-005-0770-0 [doi]
PST - ppublish
SO  - Z Rheumatol. 2005 Sep;64(6):408-15. doi: 10.1007/s00393-005-0770-0.