PMID- 16185321
OWN - NLM
STAT- MEDLINE
DCOM- 20051220
LR  - 20071115
IS  - 0001-2815 (Print)
IS  - 0001-2815 (Linking)
VI  - 66
IP  - 4
DP  - 2005 Oct
TI  - Genetic diversity of KIR natural killer cell markers in populations from France, 
      Guadeloupe, Finland, Senegal and Reunion.
PG  - 267-76
AB  - Killer cell immunoglobulin-like receptors (KIRs) belong to a diverse family of 
      natural killer (NK) cell receptors recognizing human leukocyte antigen (HLA) 
      class I molecules. Due to this functional link, KIR molecules are expected to 
      display a high polymorphism, such as their HLA ligands. Moreover, many studies 
      conducted in mouse and human models have shown that NK-KIR receptors play an 
      important role in haematopoietic stem cell transplantation (HSCT). A beneficial 
      impact of peculiar KIR ligand (HLA) mismatching has been reported suggesting a 
      role to this combinatory HLA-KIR polymorphism. It is thus important to 
      investigate KIR diversity in various human populations. To this end, we used 
      polymerase chain reaction-sequence-specific primers to evaluate KIR gene in five 
      selected populations (France, Guadeloupe, Senegal, Finland and Reunion). 
      Genotypic and haplotypic frequencies were computed, as well as genetic distances 
      and dendrogram (phylip package). These data illustrate the genetic relationship 
      of these five populations through the KIR polymorphism. Results revealed a wide 
      diversity in KIR gene frequencies in Guadeloupe and Reunion, and a high 
      specificity in Senegal. The obtained dendrogram indicated small genetic distances 
      between France, Guadeloupe and Reunion as well as between France and Finland. 
      Senegal showed a distant genetic relationship with the other countries and, 
      interestingly, an inverted ratio of coding/non-coding (KIR2DS4/1D) alleles 
      compared with Caucasians. These data expose the broad diversity in KIR genes 
      worldwide and show that KIR genes are pertinent tools in human population 
      genetics. If the role of KIR donor-recipient incompatibilities is confirmed, KIR 
      diversity according to ethnicity should be taken into account during the 
      selection of HSCT donors.
FAU - Denis, L
AU  - Denis L
AD  - HLA Laboratory, EFS Pays de Loire, Nantes, France.
FAU - Sivula, J
AU  - Sivula J
FAU - Gourraud, P-A
AU  - Gourraud PA
FAU - Kerdudou, N
AU  - Kerdudou N
FAU - Chout, R
AU  - Chout R
FAU - Ricard, C
AU  - Ricard C
FAU - Moisan, J-P
AU  - Moisan JP
FAU - Gagne, K
AU  - Gagne K
FAU - Partanen, J
AU  - Partanen J
FAU - Bignon, J-D
AU  - Bignon JD
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Tissue Antigens
JT  - Tissue antigens
JID - 0331072
RN  - 0 (HLA Antigens)
RN  - 0 (Receptors, Immunologic)
RN  - 0 (Receptors, KIR)
SB  - IM
MH  - *Alleles
MH  - Female
MH  - Finland
MH  - France
MH  - Gene Frequency/*genetics/immunology
MH  - Genetics, Population/methods
MH  - Genotype
MH  - Guadeloupe
MH  - HLA Antigens/genetics/immunology
MH  - Humans
MH  - Male
MH  - Polymorphism, Genetic/*genetics/immunology
MH  - Receptors, Immunologic/*genetics/immunology
MH  - Receptors, KIR
MH  - Reunion
MH  - Senegal
EDAT- 2005/09/28 09:00
MHDA- 2005/12/21 09:00
CRDT- 2005/09/28 09:00
PHST- 2005/09/28 09:00 [pubmed]
PHST- 2005/12/21 09:00 [medline]
PHST- 2005/09/28 09:00 [entrez]
AID - TAN473 [pii]
AID - 10.1111/j.1399-0039.2005.00473.x [doi]
PST - ppublish
SO  - Tissue Antigens. 2005 Oct;66(4):267-76. doi: 10.1111/j.1399-0039.2005.00473.x.