PMID- 16185325
OWN - NLM
STAT- MEDLINE
DCOM- 20051220
LR  - 20221207
IS  - 0001-2815 (Print)
IS  - 0001-2815 (Linking)
VI  - 66
IP  - 4
DP  - 2005 Oct
TI  - Distributions of HLA class I alleles and haplotypes in Northern Han Chinese.
PG  - 297-304
AB  - Human leukocyte antigen (HLA) class I allelic genotypes were determined in 105 
      unrelated Han ethnic individuals inhabiting the northern China area. A total of 
      19 HLA-A alleles, 49 HLA-B alleles and 24 HLA-Cw alleles were detected. Through 
      the analyses of two and three loci haplotypes of HLA-A, HLA-B, and HLA-C loci, 11 
      HLA-A-B-Cw haplotypes, 19 HLA-A-B haplotypes, 18 HLA-A-Cw haplotypes, and 24 
      HLA-B-Cw haplotypes with the frequencies of higher than 0.01 were revealed. The 
      Nei's genetic distance (GD) was estimated, and the NJ dendrogram showed that 
      Northern Han had a higher GD to Southern Han (0.233) than those to the Korean 
      (0.138) or other Northern ethnic groups, suggesting that Northern Han had more 
      mixed blood with the ethnic groups originally in Northeast Asia. Our results 
      provide useful information on the further study of evolution and relationships of 
      Chinese ethnic groups and disease association in terms of HLA class I genes.
FAU - Hong, W
AU  - Hong W
AD  - State Key Laboratory of Biocontrol, Department of Biochemistry, College of Life 
      Sciences, Sun Yat-sen University, Guangzhou, China.
FAU - Fu, Y
AU  - Fu Y
FAU - Chen, S
AU  - Chen S
FAU - Wang, F
AU  - Wang F
FAU - Ren, X
AU  - Ren X
FAU - Xu, A
AU  - Xu A
LA  - eng
PT  - Journal Article
PL  - England
TA  - Tissue Antigens
JT  - Tissue antigens
JID - 0331072
SB  - IM
MH  - *Alleles
MH  - Asian People
MH  - Biological Evolution
MH  - Asia, Eastern
MH  - Genes, MHC Class I/*genetics/immunology
MH  - Genetic Predisposition to Disease/genetics
MH  - Genetic Testing/methods
MH  - Genotype
MH  - Haplotypes/*genetics/immunology
MH  - Humans
EDAT- 2005/09/28 09:00
MHDA- 2005/12/21 09:00
CRDT- 2005/09/28 09:00
PHST- 2005/09/28 09:00 [pubmed]
PHST- 2005/12/21 09:00 [medline]
PHST- 2005/09/28 09:00 [entrez]
AID - TAN474 [pii]
AID - 10.1111/j.1399-0039.2005.00474.x [doi]
PST - ppublish
SO  - Tissue Antigens. 2005 Oct;66(4):297-304. doi: 10.1111/j.1399-0039.2005.00474.x.