PMID- 16187829
OWN - NLM
STAT- MEDLINE
DCOM- 20060123
LR  - 20061115
IS  - 0735-7044 (Print)
IS  - 0735-7044 (Linking)
VI  - 119
IP  - 4
DP  - 2005 Aug
TI  - Temporally specific extinction of conditioned responses in the rabbit 
      (Oryctolagus cuniculus) nictitating membrane preparation.
PG  - 1011-22
AB  - Extinguishing a conditioned response (CR) has entailed separating the conditioned 
      stimulus (CS) from the unconditioned stimulus (US). This research reveals that 
      elimination of the rabbit (Oryctolagus cuniculus) nictitating membrane response 
      occurred during continuous CS-US pairings. Initial training contained a mixture 
      of 2 CS-US interstimulus intervals (ISIs): 200 ms and 1,200 ms. The CRs showed 
      double peaks, one for each ISI. When 1 ISI was removed, its CR peak showed the 
      hallmarks of extinction: a decline across sessions, spontaneous recovery between 
      sessions, and rapid reacquisition when the absent ISI was reintroduced. These 
      results support real-time models of conditioning that segment the CS into 
      microstimuli while challenging theories that rely on contextual control, US 
      representations, CS processing, and response inhibition.
CI  - (c) 2005 APA
FAU - Kehoe, E James
AU  - Kehoe EJ
AD  - School of Psychology, University of New South Wales, Sydney, NSW, Australia. 
      j.kehoe@unsw.edu.au
FAU - Joscelyne, A
AU  - Joscelyne A
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Behav Neurosci
JT  - Behavioral neuroscience
JID - 8302411
SB  - IM
MH  - Adaptation, Physiological/physiology
MH  - Analysis of Variance
MH  - Animals
MH  - Behavior, Animal
MH  - Conditioning, Classical/*physiology
MH  - Extinction, Psychological/*physiology
MH  - Female
MH  - Nictitating Membrane/*physiology
MH  - Rabbits
MH  - Random Allocation
MH  - Time Factors
EDAT- 2005/09/29 09:00
MHDA- 2006/01/24 09:00
CRDT- 2005/09/29 09:00
PHST- 2005/09/29 09:00 [pubmed]
PHST- 2006/01/24 09:00 [medline]
PHST- 2005/09/29 09:00 [entrez]
AID - 2005-11024-016 [pii]
AID - 10.1037/0735-7044.119.4.1011 [doi]
PST - ppublish
SO  - Behav Neurosci. 2005 Aug;119(4):1011-22. doi: 10.1037/0735-7044.119.4.1011.