PMID- 16188059
OWN - NLM
STAT- MEDLINE
DCOM- 20091215
LR  - 20111017
IS  - 0253-3758 (Print)
IS  - 0253-3758 (Linking)
VI  - 33
IP  - 8
DP  - 2005 Aug
TI  - [Long-term effects and mortality of biventricular pacing therapy in patients with 
      congestive heart failure].
PG  - 717-9
AB  - OBJECTIVE: To study the long-term effects and mortality of biventricular pacing 
      therapy in patients with congestive heart failure. METHODS: Twenty-five patients, 
      18 men and 7 women, aged 34-75 [mean aged of (61.42 +/- 10.36)] years, with a 
      cardiac function of New York Heart Association (NYHA) class III (n = 10) or IV (n 
      = 15) received biventricular pacing therapy from Mar. 2001 to Feb. 2005. The 
      etiologies of heart failure were idiopathic dilated cardiomyopathy (16 cases), 
      hypertensive heart disease (3 cases) and ischemic heart disease (6 cases). Left 
      ventricular end-diastolic dimension (LVEDD) was > 60 mm, Left ventricular 
      ejection fraction (LVEF) was < 0.40 and QRS duration was > 130 ms in all the 
      patients. Heart function parameters were repeatedly measured before and 3 months, 
      6 months, 1 year, 2 years and 3 years after pacemaker implantation. Mortality was 
      also determined. The average follow up period was (20.88 +/- 11.51) months. 
      RESULTS: (1) Mortality: 5 patients died during follow-up (3 non-cardiac and 1 
      cardiac sudden death and 1 acute myocardial infarction). (2) The mean 6-min 
      walking distance was increased significantly (P < 0.05) at 3 months to 3 years of 
      follow-up. (3) NYHA class: The cardiac function of all patients improved 
      significantly, with a reduction of mean NYHA class of more than one grade at 3 
      months to 3 years follow-up. (4) LVEDD: LVEDD reduced significantly (P < 0.05) at 
      3 months to 3 years follow-up. (5) LVEF: LVEF increased significantly (P < 0.05) 
      at 3 months to 2 years follow-up. LVEF also improved at third year's follow-up, 
      but the difference was not significant statistically. CONCLUSIONS: Cardiac 
      resynchronization, a pacemaker-based therapy for heart failure, may enhance 
      quality of life and heart function and reverse LV remodeling. The long-term 
      effects of treatment were stable, leading to the reduction of mortality from 
      advanced heart failure.
FAU - Wang, Dong-mei
AU  - Wang DM
AD  - Department of Cardiology, General Hospital of Shenyang Command of Chinese PLA, 
      Shenyang 110016, China.
FAU - Han, Ya-ling
AU  - Han YL
FAU - Zang, Hong-yun
AU  - Zang HY
FAU - Zhou, Wei-wei
AU  - Zhou WW
FAU - Jing, Quan-min
AU  - Jing QM
FAU - Wang, Zu-lu
AU  - Wang ZL
FAU - Wang, Shou-li
AU  - Wang SL
FAU - Li, Fei
AU  - Li F
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Zhonghua Xin Xue Guan Bing Za Zhi
JT  - Zhonghua xin xue guan bing za zhi
JID - 7910682
SB  - IM
MH  - Adult
MH  - Aged
MH  - Cardiac Pacing, Artificial/*methods
MH  - Death, Sudden, Cardiac
MH  - Female
MH  - Heart Failure/*mortality/physiopathology/*therapy
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Pacemaker, Artificial
MH  - Survival Rate
MH  - Treatment Outcome
EDAT- 2005/09/29 09:00
MHDA- 2009/12/16 06:00
CRDT- 2005/09/29 09:00
PHST- 2005/09/29 09:00 [pubmed]
PHST- 2009/12/16 06:00 [medline]
PHST- 2005/09/29 09:00 [entrez]
PST - ppublish
SO  - Zhonghua Xin Xue Guan Bing Za Zhi. 2005 Aug;33(8):717-9.