PMID- 16190385
OWN - NLM
STAT- MEDLINE
DCOM- 20060901
LR  - 20071115
IS  - 1672-7347 (Print)
IS  - 1672-7347 (Linking)
VI  - 30
IP  - 4
DP  - 2005 Aug
TI  - [Changes of myocardial fibrotic indices and its mechanism in patients with 
      ischemic cardiomyopathy].
PG  - 410-2
AB  - OBJECTIVE: To investigate the myocardial fibrotic indices in patients with 
      ischemic cardiomyopathy (ICM), and explore the mechanism of myocardial fibrosis. 
      METHODS: The concentration of serum procollagen type III aminoterminal peptide (P 
      III P), procollagen type IV aminoterminal peptide (P IV P), lamnin (LN), and 
      hyaluronic acid (HA), as well as plasma angiotension II (AngII), aldosterone 
      (ALD), and transforming growth factor beta 1 (TGFbeta1) in 46 ICM patients and 37 
      normal controls were measured by radioimmunoassay (RIA). The correlations between 
      the plasma levels of AngII, ADL, TGFbeta1, and serum levels of P III P, P IV P, 
      LN, and HA were analyzed. RESULTS: Compared with normal controls, the 
      concentrations of serum P III P, P IV P, LN, HA, and plasma AngII, ADL, and 
      TGfbeta1, significantly increased in ICM patients. AngII, ALD, and TGFbeta1 
      levels were positively correlated with the indices of myocardial fibrosis. 
      CONCLUSION: The myocardial fibrosis exists in ICM patients and the serum 
      concentrations of P III P, P IV P, LN, and HA may be an indirect index of 
      myocardial fibrosis. AngII, ADL, and TGFbeta1 levels play important roles in 
      myocardial fibrosis.
FAU - Zhang, Guo-gang
AU  - Zhang GG
AD  - Department of Cardiology, Xiangya Hospital, Central South University, Changsha 
      410008, China. zyzzgg@sina.com
FAU - Zhang, Sai-dan
AU  - Zhang SD
FAU - Ouyang, Xi-ping
AU  - Ouyang XP
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Zhong Nan Da Xue Xue Bao Yi Xue Ban
JT  - Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. 
      Medical sciences
JID - 101230586
RN  - 0 (Collagen Type III)
RN  - 0 (Laminin)
RN  - 9004-61-9 (Hyaluronic Acid)
SB  - IM
MH  - Aged
MH  - Cardiomyopathies/*pathology
MH  - Collagen Type III/blood
MH  - Coronary Artery Disease/*pathology
MH  - Female
MH  - Fibrosis/pathology
MH  - Humans
MH  - Hyaluronic Acid/blood
MH  - Laminin/blood
MH  - Male
MH  - Middle Aged
MH  - Myocardium/*pathology
EDAT- 2005/09/30 09:00
MHDA- 2006/09/02 09:00
CRDT- 2005/09/30 09:00
PHST- 2005/09/30 09:00 [pubmed]
PHST- 2006/09/02 09:00 [medline]
PHST- 2005/09/30 09:00 [entrez]
PST - ppublish
SO  - Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2005 Aug;30(4):410-2.