PMID- 16192720
OWN - NLM
STAT- MEDLINE
DCOM- 20060123
LR  - 20050929
IS  - 1424-859X (Electronic)
IS  - 1424-8581 (Linking)
VI  - 111
IP  - 3-4
DP  - 2005
TI  - Pesticides and the induction of aneuploidy in human sperm.
PG  - 378-83
AB  - Pesticides are some of the most frequently released toxic chemicals into the 
      environment. Exposure to them has been associated with reproductive dysfunction, 
      but the knowledge of the genotoxic risks of these substances is still limited. In 
      vitro and in vivo, many pesticides are shown to induce aneuploidy. Analysis of 
      sperm chromosomes by fluorescence in situ hybridization (FISH) with 
      chromosome-specific probes has obtained increasing popularity in genetic 
      toxicology. Sperm-FISH studies on men exposed to pesticides have yielded 
      conflicting results: in men exposed to multiple pesticides during spraying no 
      increased disomy frequencies in sperm were observed, although one study reported 
      an increased rate of sex chromosome nullisomy. In contrast the two studies 
      conducted in pesticide factories showed increased frequencies of sperm aneuploidy 
      in exposed men compared to controls. The available data indicates that at least 
      some of the commonly used pesticides are capable of inducing aneuploidy in human 
      sperm when the exposure level is high enough.
CI  - Copyright 2005 S. Karger AG, Basel.
FAU - Harkonen, K
AU  - Harkonen K
AD  - Department of Obstetrics and Gynecology, Turku University Central Hospital, 
      Turku, Finland. kajohar@utu.fi
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Switzerland
TA  - Cytogenet Genome Res
JT  - Cytogenetic and genome research
JID - 101142708
RN  - 0 (Aneugens)
RN  - 0 (Mutagens)
RN  - 0 (Pesticides)
SB  - IM
MH  - Aneugens/*toxicity
MH  - *Aneuploidy
MH  - Animals
MH  - Female
MH  - Humans
MH  - Male
MH  - Mutagens
MH  - Pesticides/*adverse effects
MH  - Spermatozoa/abnormalities/*drug effects
RF  - 96
EDAT- 2005/09/30 09:00
MHDA- 2006/01/24 09:00
CRDT- 2005/09/30 09:00
PHST- 2004/11/01 00:00 [received]
PHST- 2005/01/17 00:00 [accepted]
PHST- 2005/09/30 09:00 [pubmed]
PHST- 2006/01/24 09:00 [medline]
PHST- 2005/09/30 09:00 [entrez]
AID - 86915 [pii]
AID - 10.1159/000086915 [doi]
PST - ppublish
SO  - Cytogenet Genome Res. 2005;111(3-4):378-83. doi: 10.1159/000086915.