PMID- 16192986
OWN - NLM
STAT- MEDLINE
DCOM- 20060706
LR  - 20151119
IS  - 0893-133X (Print)
IS  - 0893-133X (Linking)
VI  - 31
IP  - 2
DP  - 2006 Feb
TI  - Plasma drug concentrations and physiological measures in 'dance party' 
      participants.
PG  - 424-30
AB  - The increasing use of (+/-) 3,4-methylenedioxymethamphetamine (MDMA) in the 
      setting of large dance parties ('raves') and clubs has been the source of some 
      concern, because of potential acute adverse events, and because animal studies 
      suggest that MDMA has the potential to damage brain serotonin (5-HT) neurons. 
      However, it is not yet known whether MDMA, as used in the setting of dance 
      parties, leads to plasma levels of MDMA that are associated with toxicity to 5-HT 
      neurons in animals. The present study sought to address this question. Plasma 
      MDMA concentrations, vital signs, and a variety of blood and urine measures were 
      obtained prior to, and hours after, individuals attended a dance party. After the 
      dance party, subjects were without clinical complaints, had measurable amounts of 
      residual MDMA in plasma, and nearly half of the subjects also tested positive for 
      methamphetamine, another amphetamine analog that has been shown to have 5-HT 
      neurotoxic potential in animals. Plasma concentrations of MDMA did not correlate 
      with self-reported use of 'ecstasy' and, in some subjects, overlapped with those 
      that have been associated with 5-HT neurotoxicity in non-human primates. 
      Additional subjects were likely to have had similar concentrations while at the 
      dance party, when one considers the reported time of drug ingestion and the 
      plasma half-life of MDMA in humans. Hematological and biochemical analyses were 
      generally unremarkable. Moderate increases in blood pressure, heart rate and body 
      temperature were observed in the subjects with the highest MDMA plasma 
      concentrations. These findings are consistent with epidemiological findings that 
      most people who use MDMA at dance parties do not develop serious clinical 
      complications, and suggest that some of these individuals may be at risk for 
      developing MDMA-induced toxicity to brain serotonin neurons.
FAU - Irvine, Rodney J
AU  - Irvine RJ
AD  - Department of Clinical and Experimental Pharmacology, University of Adelaide, SA, 
      Australia. rod.irvine@adelaide.edu.au
FAU - Keane, Michael
AU  - Keane M
FAU - Felgate, Peter
AU  - Felgate P
FAU - McCann, Una D
AU  - McCann UD
FAU - Callaghan, Paul D
AU  - Callaghan PD
FAU - White, Jason M
AU  - White JM
LA  - eng
GR  - DA10217/DA/NIDA NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Neuropsychopharmacology
JT  - Neuropsychopharmacology : official publication of the American College of 
      Neuropsychopharmacology
JID - 8904907
RN  - 0 (Hallucinogens)
RN  - 44RAL3456C (Methamphetamine)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - Adult
MH  - Body Temperature/drug effects
MH  - *Dancing
MH  - Demography
MH  - Female
MH  - Hallucinogens/administration & dosage/*blood/urine
MH  - Heart Rate/drug effects
MH  - Humans
MH  - Male
MH  - Methamphetamine/administration & dosage/blood/urine
MH  - N-Methyl-3,4-methylenedioxyamphetamine/*administration & dosage/*blood/urine
MH  - Radioimmunoassay/methods
MH  - Surveys and Questionnaires
EDAT- 2005/09/30 09:00
MHDA- 2006/07/11 09:00
CRDT- 2005/09/30 09:00
PHST- 2005/09/30 09:00 [pubmed]
PHST- 2006/07/11 09:00 [medline]
PHST- 2005/09/30 09:00 [entrez]
AID - 1300896 [pii]
AID - 10.1038/sj.npp.1300896 [doi]
PST - ppublish
SO  - Neuropsychopharmacology. 2006 Feb;31(2):424-30. doi: 10.1038/sj.npp.1300896.