PMID- 16195825
OWN - NLM
STAT- MEDLINE
DCOM- 20051206
LR  - 20181113
IS  - 1058-0468 (Print)
IS  - 1058-0468 (Linking)
VI  - 22
IP  - 7-8
DP  - 2005 Aug
TI  - Aneuploidy involving chromosome 1 in failed-fertilized human oocytes is unrelated 
      to maternal age.
PG  - 285-93
AB  - PURPOSE: To study whether maternal meiotic errors in failed-fertilized oocytes 
      involving chromosome 1 occur at frequencies similar to those involving other 
      autosomes, and whether their frequency is affected by maternal age. METHODS: 
      Using fluorescence in situ hybridization (FISH), frequencies of aneusomy and 
      chromatid pre-division involving chromosomes 1, 16, 18, and 21 were determined 
      for 273 failed-fertilized oocytes. RESULTS: The aneuploidy rate for chromosome 1 
      was 15.8%, and was neither age-dependent nor significantly different from that 
      for chromosomes 16, 18 or 21. Only chromosome 16 exhibited an age-dependent 
      increase in aneusomy rates. The frequency of chromatid pre-division was lower for 
      chromosome 1 than for chromosome 18 (11.9% vs. 25.4%; p = 0.01), but not 
      different from that for chromosomes 16 or 21. CONCLUSION: Aneuploidy involving 
      chromosome 1 in failed-fertilized oocytes is unrelated to maternal age and occurs 
      at a frequency similar to that for chromosomes 16, 18, and 21.
FAU - Weier, Jingly Fung
AU  - Weier JF
AD  - Department of Obstetrics, Gynecology, and Reproductive Sciences, School of 
      Medicine, University of California, San Francisco, USA. jlfung@itsa.ucsf.edu
FAU - Weier, Heinz-Ulrich G
AU  - Weier HU
FAU - Nureddin, Aida
AU  - Nureddin A
FAU - Pedersen, Roger A
AU  - Pedersen RA
FAU - Racowsky, Catherine
AU  - Racowsky C
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - J Assist Reprod Genet
JT  - Journal of assisted reproduction and genetics
JID - 9206495
SB  - IM
MH  - *Aneuploidy
MH  - *Chromosomes, Human, Pair 1
MH  - Chromosomes, Human, Pair 16
MH  - Chromosomes, Human, Pair 18
MH  - Chromosomes, Human, Pair 21
MH  - Female
MH  - Fertilization in Vitro
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Karyotyping
MH  - *Maternal Age
MH  - Meiosis
MH  - Metaphase
MH  - *Oocytes
MH  - Pregnancy
EDAT- 2005/10/01 09:00
MHDA- 2005/12/13 09:00
CRDT- 2005/10/01 09:00
PHST- 2004/12/02 00:00 [received]
PHST- 2005/03/14 00:00 [accepted]
PHST- 2005/10/01 09:00 [pubmed]
PHST- 2005/12/13 09:00 [medline]
PHST- 2005/10/01 09:00 [entrez]
AID - 10.1007/s10815-005-5999-7 [doi]
PST - ppublish
SO  - J Assist Reprod Genet. 2005 Aug;22(7-8):285-93. doi: 10.1007/s10815-005-5999-7.