PMID- 16195883
OWN - NLM
STAT- MEDLINE
DCOM- 20060329
LR  - 20181113
IS  - 1439-6319 (Print)
IS  - 1439-6319 (Linking)
VI  - 95
IP  - 5-6
DP  - 2005 Dec
TI  - The effects of carbohydrate supplementation during the second of two prolonged 
      cycling bouts on immunoendocrine responses.
PG  - 391-9
AB  - The purpose of this study was to examine the effect of carbohydrate (CHO) feeding 
      during the second of two 90-min cycling bouts (EX1 started at 09:00 and EX2 
      started at 13:30) at 60% VO2max on leucocyte redistribution, neutrophil 
      degranulation and oxidative burst and plasma IL-6 and stress hormone responses. 
      This study consisted of two trials, which were completed in a counterbalanced 
      order and separated by at least 4 days. Subjects (n=9) consumed a lemon flavoured 
      10% w/v CHO (glucose) or placebo (PLA) beverage during EX2: 500 ml just before 
      exercise and 250 ml every 20 min during exercise. Venous blood samples were taken 
      5 min before exercise, immediately post-exercise, and 18-h post-EX2 for both 
      trials. The main findings of this study were that ingestion of CHO compared with 
      PLA during EX2 better maintained plasma glucose concentration, blunted the 
      responses of plasma adrenaline, ACTH, cortisol, GH and IL-6, and attenuated the 
      leukocytosis and monocytosis, but had no effect on neutrophil degranulation and 
      oxidative burst activity. Furthermore, the immunoendocrine disturbances induced 
      by two bouts of prolonged exercise returned to resting values within 18 h. These 
      findings suggest that ingestion of CHO compared with PLA during the second of two 
      bouts of 90-min cycling at 60% VO2max better maintains plasma glucose, blunts 
      hypothalamic-pituitary-adrenal activation, and attenuates leucocyte trafficking, 
      but does not affect neutrophil function. Furthermore, the disturbances of 
      immunoendocrine responses induced by two bouts of prolonged exercise on the same 
      day recover within 18 h.
FAU - Li, Tzai-Li
AU  - Li TL
AD  - Institute School of Sport and Exercise Sciences, Loughborough University, 
      Loughborough, LE11 3TU, UK. M.Gleeson@lboro.ac.uk
FAU - Gleeson, Michael
AU  - Gleeson M
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
DEP - 20050930
PL  - Germany
TA  - Eur J Appl Physiol
JT  - European journal of applied physiology
JID - 100954790
RN  - 0 (Blood Glucose)
RN  - 0 (Dietary Carbohydrates)
RN  - 0 (Interleukin-6)
RN  - 9002-60-2 (Adrenocorticotropic Hormone)
RN  - 9002-72-6 (Growth Hormone)
RN  - WI4X0X7BPJ (Hydrocortisone)
RN  - YKH834O4BH (Epinephrine)
SB  - IM
MH  - Adrenocorticotropic Hormone/blood
MH  - Adult
MH  - Blood Glucose/metabolism
MH  - Cell Migration Inhibition
MH  - Dietary Carbohydrates/*administration & dosage
MH  - *Dietary Supplements
MH  - Epinephrine/blood
MH  - Exercise/*physiology
MH  - Exercise Test
MH  - Growth Hormone/blood
MH  - Humans
MH  - Hydrocortisone/blood
MH  - Hypothalamo-Hypophyseal System/*metabolism
MH  - Interleukin-6/metabolism
MH  - Leukocyte Count
MH  - Leukocytes/*immunology
MH  - Male
MH  - Neutrophils/immunology
MH  - Physical Exertion/physiology
MH  - Pituitary-Adrenal System/*metabolism
MH  - Respiratory Burst/physiology
MH  - Time Factors
EDAT- 2005/10/01 09:00
MHDA- 2006/03/30 09:00
CRDT- 2005/10/01 09:00
PHST- 2005/06/23 00:00 [accepted]
PHST- 2005/10/01 09:00 [pubmed]
PHST- 2006/03/30 09:00 [medline]
PHST- 2005/10/01 09:00 [entrez]
AID - 10.1007/s00421-005-0024-5 [doi]
PST - ppublish
SO  - Eur J Appl Physiol. 2005 Dec;95(5-6):391-9. doi: 10.1007/s00421-005-0024-5. Epub 
      2005 Sep 30.