PMID- 16196202
OWN - NLM
STAT- MEDLINE
DCOM- 20051024
LR  - 20151119
IS  - 0236-5383 (Print)
IS  - 0236-5383 (Linking)
VI  - 56
IP  - 3-4
DP  - 2005
TI  - Influence of antipyretic drugs on the labeling of blood elements with 
      technetium-99m.
PG  - 275-82
AB  - Acetaminophen (AAP), acetylsalicylic acid (ASA) and dipyrone (DIP) are 
      antipyretic and analgesics drugs that have wide use in health sciences. Some 
      drugs can modify the labeling of blood elements with technetium-99m (99mTc). This 
      work has evaluated the effect of AAP, ASA and DIP on the labeling of the blood 
      elements with 99mTc. Blood was incubated with different concentrations of the 
      drugs before the 99mTc-labeled process. Plasma (P), blood cells (BC), insoluble 
      (IF-P, IF-BC) and soluble (SF-P, SF-BC) fractions were separated and percentage 
      of radioactivity (%ATI) in each fraction was determined. Data have shown that the 
      antipyretic drugs used in this study did not significantly modify the fixation of 
      99mTc on the blood elements when the experiments were carried out with the doses 
      usually used in human beings. Although the experiments were carried out with 
      rats, it is possible to suggest that AAP, ASA or DIP should not interfere with 
      the procedures in nuclear medicine involving the labeling of blood elements with 
      99mTc.
FAU - Fonseca, A S
AU  - Fonseca AS
AD  - Departamento de Farmacologia e Psicobiologia, Instituto de Biologia Roberto 
      Alcantara Gomes, Universidade do Estado do Rio de Janeiro, Av. 28 de Setembro 87, 
      fundos, 5 andar, 20551-030, Rio de Janeiro, Brasil. adenilso@uerj.br
FAU - Frydman, J N G
AU  - Frydman JN
FAU - Santos, R
AU  - Santos R
FAU - Bernardo-Filho, M
AU  - Bernardo-Filho M
LA  - eng
PT  - Journal Article
PL  - Hungary
TA  - Acta Biol Hung
JT  - Acta biologica Hungarica
JID - 8404358
RN  - 0 (Analgesics, Non-Narcotic)
RN  - 0 (Blood Proteins)
RN  - 362O9ITL9D (Acetaminophen)
RN  - 6429L0L52Y (Dipyrone)
RN  - 7440-26-8 (Technetium)
RN  - R16CO5Y76E (Aspirin)
SB  - IM
MH  - Acetaminophen/metabolism
MH  - Analgesics, Non-Narcotic/*metabolism
MH  - Animals
MH  - Aspirin/metabolism
MH  - Blood Cells/*metabolism
MH  - Blood Proteins/*metabolism
MH  - Dipyrone/metabolism
MH  - Humans
MH  - *Isotope Labeling
MH  - Male
MH  - Plasma/*metabolism
MH  - Rats
MH  - Rats, Wistar
MH  - Technetium/*metabolism
EDAT- 2005/10/04 09:00
MHDA- 2005/10/26 09:00
CRDT- 2005/10/04 09:00
PHST- 2005/10/04 09:00 [pubmed]
PHST- 2005/10/26 09:00 [medline]
PHST- 2005/10/04 09:00 [entrez]
AID - 10.1556/ABiol.56.2005.3-4.10 [doi]
PST - ppublish
SO  - Acta Biol Hung. 2005;56(3-4):275-82. doi: 10.1556/ABiol.56.2005.3-4.10.