PMID- 16198010 OWN - NLM STAT- MEDLINE DCOM- 20060620 LR - 20131121 IS - 0167-0115 (Print) IS - 0167-0115 (Linking) VI - 132 IP - 1-3 DP - 2005 Dec 15 TI - Interaction between arginine vasopressin and angiotensin II receptors in the central regulation of sodium balance. PG - 53-8 AB - We speculated that the influence of lateral preoptic area (LPO) in sodium balance, involves arginine8-vasopressin (AVP) and angiotensin (ANG II) on Na+ uptake in LPO. Therefore, the present study investigated the effects of central administration of specific AVP and ANG II antagonists (d(CH2)5-Tyr (Me)-AVP (AAVP) and [Adamanteanacetyl1, 0-ET-d-Tyr2, Val4, Aminobutyryl6, Arg(8,9)]-AVP (ATAVP) antagonists of V1 and V2 receptors of AVP. Also the effects of losartan and CGP42112A (selective ligands of the AT1 and AT2 angiotensin receptors, respectively), was investigated on Na+ uptake and renal fluid and electrolyte excretion. After an acclimatization period of 7 days, the animals were maintained under tribromoethanol (200 mg/kg body weight, intraperitonial) anesthesia and placed in a Kopf stereotaxic instrument. Stainless guide cannula was implanted into the LPO. AAVP and ATAVP injected into the LPO prior to AVP produced a reduction in the NaCl intake. Both the AT1 and AT2 ligands administered into the LPO elicited a decrease in the NaCl intake induced by AVP injected into the LPO. AVP injection into the LPO increased sodium renal excretion, but this was reduced by prior AAVP administration. The ATAVP produced a decreased in the natriuretic effect of AVP. The losartan injected into LPO previous to AVP decreased the sodium excretion and the CGP 421122A also decreased the natriuretic effect of AVP. The AVP produced an antidiuresis effect that was inhibited by prior administration into LPO of the ATAVP. The AAVP produced no change in the antidiuretic effect of AVP. These results suggest that LPO are implicated in sodium balance that is mediated by V1, V2, AT1 and AT2 receptors. FAU - Saad, Wilson Abrao AU - Saad WA AD - Basic Institute of Biosciences- UNITAU-Taubate SP, Brazil. saad@foar.unesp.br FAU - Camargo, Luiz Antonio de Arruda AU - Camargo LA FAU - Antunes-Rodrigues, Jose AU - Antunes-Rodrigues J FAU - Saad, William Abrao AU - Saad WA FAU - Guarda, Ismael Franscisco Motta Sigueira AU - Guarda IF FAU - Guarda, Renata Saad AU - Guarda RS LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20050928 PL - Netherlands TA - Regul Pept JT - Regulatory peptides JID - 8100479 RN - 0 (Angiotensin II Type 1 Receptor Blockers) RN - 0 (Angiotensin Receptor Antagonists) RN - 0 (Oligopeptides) RN - 0 (Receptors, Angiotensin) RN - 0 (Receptors, Vasopressin) RN - 11128-99-7 (Angiotensin II) RN - 113-79-1 (Arginine Vasopressin) RN - 127060-75-7 (CGP 42112A) RN - 73168-24-8 (vasopressin, 1-(1-mercaptocyclohexaneacetic acid)-2-(O- methyl-L-tyrosine)-8-L-arginine-) RN - 9NEZ333N27 (Sodium) RN - JMS50MPO89 (Losartan) SB - IM MH - Angiotensin II/antagonists & inhibitors MH - Angiotensin II Type 1 Receptor Blockers/*pharmacology MH - *Angiotensin Receptor Antagonists MH - Animals MH - Arginine Vasopressin/analogs & derivatives/*antagonists & inhibitors/pharmacology/physiology MH - Blood Pressure MH - Dose-Response Relationship, Drug MH - Hypothalamus/metabolism MH - Injections, Intraventricular MH - Losartan/pharmacology MH - Male MH - Oligopeptides/pharmacology MH - Rats MH - Rats, Sprague-Dawley MH - Receptors, Angiotensin/physiology MH - Receptors, Vasopressin/*administration & dosage MH - Sodium/*metabolism EDAT- 2005/10/04 09:00 MHDA- 2006/06/21 09:00 CRDT- 2005/10/04 09:00 PHST- 2005/01/27 00:00 [received] PHST- 2005/09/08 00:00 [accepted] PHST- 2005/10/04 09:00 [pubmed] PHST- 2006/06/21 09:00 [medline] PHST- 2005/10/04 09:00 [entrez] AID - S0167-0115(05)00192-8 [pii] AID - 10.1016/j.regpep.2005.09.003 [doi] PST - ppublish SO - Regul Pept. 2005 Dec 15;132(1-3):53-8. doi: 10.1016/j.regpep.2005.09.003. Epub 2005 Sep 28.