PMID- 16198214
OWN - NLM
STAT- MEDLINE
DCOM- 20060113
LR  - 20220330
IS  - 0738-3991 (Print)
IS  - 0738-3991 (Linking)
VI  - 59
IP  - 1
DP  - 2005 Oct
TI  - Development and validation of the immunosuppressant therapy adherence instrument 
      (ITAS).
PG  - 13-20
AB  - A five-item scale was developed that asked respondents to indicate how often they 
      were non-adherent to immunosuppressant therapy (IST) given a particular 
      circumstance. Two hundred and twenty-two recipients completed the instrument. 
      Validity of the scale was assessed by correlating composite item scores with 
      refill record adherence rates (RRARs), serum immunosuppressant (IS) 
      concentrations, graft rejection, and increased serum creatinine (SCr) levels. One 
      scale item was deleted due to lack of response variability. Cronbach's alpha 
      coefficient for the four-item scale was 0.81, demonstrating that the scale has 
      acceptable reliability. All items loaded on a single principal component, 
      suggesting that the scale measures a single adherence construct, which accounted 
      for 64% of the scale items' variance. The four-item scale, adherence measured by 
      IS RRARs, and "target" IS serum concentrations had positive correlations (p < 
      0.01). Item scores were shown to be negatively related to rejection occurrence 
      and increased SCr (p < 0.05). The immunosuppressant therapy adherence scale is 
      the first published, valid and reliable instrument that measures recipients IST 
      adherence.
FAU - Chisholm, Marie A
AU  - Chisholm MA
AD  - University of Georgia College of Pharmacy, USA. mchisol@mail.mcg.edu
FAU - Lance, Charles E
AU  - Lance CE
FAU - Williamson, Gail M
AU  - Williamson GM
FAU - Mulloy, Laura L
AU  - Mulloy LL
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Validation Study
PL  - Ireland
TA  - Patient Educ Couns
JT  - Patient education and counseling
JID - 8406280
RN  - 0 (Immunosuppressive Agents)
RN  - AYI8EX34EU (Creatinine)
MH  - Attitude to Health
MH  - Creatinine/blood
MH  - Data Interpretation, Statistical
MH  - Drug Administration Schedule
MH  - Female
MH  - Graft Rejection
MH  - Graft Survival
MH  - Humans
MH  - Immunosuppressive Agents/*administration & dosage
MH  - Male
MH  - Middle Aged
MH  - *Organ Transplantation
MH  - *Patient Compliance
MH  - *Surveys and Questionnaires
EDAT- 2005/10/04 09:00
MHDA- 2006/01/18 09:00
CRDT- 2005/10/04 09:00
PHST- 2004/05/27 00:00 [received]
PHST- 2004/08/17 00:00 [revised]
PHST- 2004/09/06 00:00 [accepted]
PHST- 2005/10/04 09:00 [pubmed]
PHST- 2006/01/18 09:00 [medline]
PHST- 2005/10/04 09:00 [entrez]
AID - S0738-3991(04)00306-4 [pii]
AID - 10.1016/j.pec.2004.09.003 [doi]
PST - ppublish
SO  - Patient Educ Couns. 2005 Oct;59(1):13-20. doi: 10.1016/j.pec.2004.09.003.