PMID- 16198243
OWN - NLM
STAT- MEDLINE
DCOM- 20060228
LR  - 20151119
IS  - 1071-9164 (Print)
IS  - 1071-9164 (Linking)
VI  - 11
IP  - 7
DP  - 2005 Sep
TI  - Plasma natriuretic peptides up to 2 years after acute myocardial infarction and 
      relation to prognosis: an OPTIMAAL substudy.
PG  - 492-7
AB  - BACKGROUND: Few studies have compared the relative prognostic value of different 
      natriuretic peptides after acute myocardial infarction (AMI). None has described 
      peptide levels beyond the early post-AMI period. This study describes temporal 
      profiles of 4 natriuretic peptides to 2 years after AMI and relationship with 
      outcome. METHODS AND RESULTS: We assessed profiles of N-terminal proANP (N-ANP), 
      B-type natriuretic peptide (BNP), N-terminal proBNP (N-BNP), and C-type 
      natriuretic peptide (CNP) (study entry, 1 month, 1 year, and 2 years) in 236 
      patients with AMI complicated by clinical or radiologic evidence of heart 
      failure. We assessed the prognostic value for baseline levels of each peptide for 
      death or reinfarction. We observed distinct natriuretic peptide profiles. BNP and 
      N-BNP levels were highest at baseline and fell thereafter. N-ANP levels increased 
      from baseline to 30 days and fell thereafter. During follow-up (mean 938 days), 
      34 patients died and a further 25 suffered nonfatal AMI. Baseline natriuretic 
      peptide levels did not have independent predictive power for outcome. N-BNP 
      levels fell from baseline to 30 days in patients surviving to the end of 
      follow-up (P = .005) but were similar at both times (P = .76) for those dying 
      after 30 days. Age (P < .0005) and change in N-BNP from baseline to 30 days (P = 
      .026) had independent predictive value for death after 30 days. CONCLUSION: 
      N-ANP, BNP, N-BNP, and CNP show distinct plasma profiles after AMI. Failure of 
      plasma N-BNP to fall in the 30 days after AMI indicates adverse prognosis.
FAU - Squire, Iain B
AU  - Squire IB
AD  - University of Leicester Department of Cardiovascular Sciences, Leicester, United 
      Kingdom.
FAU - Orn, Stein
AU  - Orn S
FAU - Ng, Leong L
AU  - Ng LL
FAU - Manhenke, Cord
AU  - Manhenke C
FAU - Shipley, Lorraine
AU  - Shipley L
FAU - Aarsland, Torbjorn
AU  - Aarsland T
FAU - Dickstein, Kenneth
AU  - Dickstein K
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Card Fail
JT  - Journal of cardiac failure
JID - 9442138
RN  - 0 (Biomarkers)
RN  - 0 (Peptide Fragments)
RN  - 0 (pro-brain natriuretic peptide (1-76))
RN  - 114471-18-0 (Natriuretic Peptide, Brain)
RN  - 127869-51-6 (Natriuretic Peptide, C-Type)
RN  - 85637-73-6 (Atrial Natriuretic Factor)
RN  - AYI8EX34EU (Creatinine)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Atrial Natriuretic Factor/blood
MH  - Biomarkers/*blood
MH  - Creatinine/blood
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - Myocardial Infarction/*blood/*diagnosis
MH  - Natriuretic Peptide, Brain/blood
MH  - Natriuretic Peptide, C-Type/blood
MH  - Peptide Fragments/blood
MH  - Predictive Value of Tests
MH  - Prognosis
MH  - Survival Analysis
EDAT- 2005/10/04 09:00
MHDA- 2006/03/01 09:00
CRDT- 2005/10/04 09:00
PHST- 2005/02/09 00:00 [received]
PHST- 2005/05/02 00:00 [revised]
PHST- 2005/05/09 00:00 [accepted]
PHST- 2005/10/04 09:00 [pubmed]
PHST- 2006/03/01 09:00 [medline]
PHST- 2005/10/04 09:00 [entrez]
AID - S1071-9164(05)00207-1 [pii]
AID - 10.1016/j.cardfail.2005.05.004 [doi]
PST - ppublish
SO  - J Card Fail. 2005 Sep;11(7):492-7. doi: 10.1016/j.cardfail.2005.05.004.