PMID- 16198291
OWN - NLM
STAT- MEDLINE
DCOM- 20051121
LR  - 20181113
IS  - 1534-5807 (Print)
IS  - 1878-1551 (Electronic)
IS  - 1534-5807 (Linking)
VI  - 9
IP  - 4
DP  - 2005 Oct
TI  - Cyclin D regulation of a sexually dimorphic asymmetric cell division.
PG  - 489-99
AB  - The C. elegans somatic gonadal precursor cell (SGP) divides asymmetrically to 
      establish gonad-specific coordinates in both sexes. In addition, the SGP division 
      is sexually dimorphic and initiates sex-specific programs of gonadogenesis. 
      Wnt/MAPK signaling determines the gonadal axes, and the FKH-6 transcription 
      factor specifies the male mode of SGP division. In this paper, we demonstrate 
      that C. elegans cyclin D controls POP-1/TCF asymmetry in the SGP daughters as 
      well as fkh-6 and rnr expression in the SGPs. Although cyclin D mutants have 
      delayed SGP divisions, the cyclin D defects are not mimicked by other methods of 
      retarding the SGP division. We find that EFL-1/E2F has an antagonistic effect on 
      fkh-6 expression and gonadogenesis, which is relieved by cyclin D activity. We 
      propose that cyclin D and other canonical regulators of the G1/S transition 
      coordinate key regulators of axis formation and sex determination with cell cycle 
      progression to achieve the sexually dimorphic SGP asymmetric division.
FAU - Tilmann, Christopher
AU  - Tilmann C
AD  - Department of Biochemistry, University of Wisconsin-Madison, Madison, Wisconsin 
      53706, USA. cetilmann@loyola.edu
FAU - Kimble, Judith
AU  - Kimble J
LA  - eng
GR  - F32 GM069716/GM/NIGMS NIH HHS/United States
GR  - F32 GM069716-01/GM/NIGMS NIH HHS/United States
GR  - F32 GM069716-02/GM/NIGMS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Dev Cell
JT  - Developmental cell
JID - 101120028
RN  - 0 (Caenorhabditis elegans Proteins)
RN  - 0 (Cell Cycle Proteins)
RN  - 0 (Cyclin D)
RN  - 0 (Cyclins)
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Forkhead Transcription Factors)
RN  - 0 (High Mobility Group Proteins)
RN  - 0 (Recombinant Fusion Proteins)
RN  - 0 (Transcription Factors)
RN  - 0 (cyd-1 protein, C elegans)
RN  - 0 (fkh-6 protein, C elegans)
RN  - 0 (pop-1 protein, C elegans)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Caenorhabditis elegans/*anatomy & histology/*growth & development/physiology
MH  - Caenorhabditis elegans Proteins/genetics/metabolism
MH  - Cell Cycle Proteins/genetics/metabolism
MH  - Cell Division/*physiology
MH  - Cyclin D
MH  - Cyclins/genetics/*metabolism
MH  - DNA-Binding Proteins/genetics/metabolism
MH  - Female
MH  - Forkhead Transcription Factors/genetics/metabolism
MH  - *Gonads/anatomy & histology/growth & development
MH  - High Mobility Group Proteins/genetics/metabolism
MH  - Male
MH  - Molecular Sequence Data
MH  - Morphogenesis
MH  - Mutation, Missense
MH  - Recombinant Fusion Proteins/genetics/metabolism
MH  - Sequence Alignment
MH  - *Sex Characteristics
MH  - Signal Transduction/physiology
MH  - Transcription Factors/genetics/metabolism
PMC - PMC1513624
MID - NIHMS5160
EDAT- 2005/10/04 09:00
MHDA- 2005/12/13 09:00
PMCR- 2006/07/22
CRDT- 2005/10/04 09:00
PHST- 2005/05/31 00:00 [received]
PHST- 2005/08/15 00:00 [revised]
PHST- 2005/09/07 00:00 [accepted]
PHST- 2005/10/04 09:00 [pubmed]
PHST- 2005/12/13 09:00 [medline]
PHST- 2005/10/04 09:00 [entrez]
PHST- 2006/07/22 00:00 [pmc-release]
AID - S1534-5807(05)00339-4 [pii]
AID - 10.1016/j.devcel.2005.09.004 [doi]
PST - ppublish
SO  - Dev Cell. 2005 Oct;9(4):489-99. doi: 10.1016/j.devcel.2005.09.004.