PMID- 16198569
OWN - NLM
STAT- MEDLINE
DCOM- 20060227
LR  - 20240109
IS  - 0962-8924 (Print)
IS  - 0962-8924 (Linking)
VI  - 15
IP  - 11
DP  - 2005 Nov
TI  - COP1 - from plant photomorphogenesis to mammalian tumorigenesis.
PG  - 618-25
AB  - The COP1 (constitutive photomorphogenic 1) protein, comprising RING finger, 
      coiled-coil and WD40 domains, is conserved in both higher plants and vertebrates. 
      In plants, COP1 acts as an E3 ubiquitin ligase to repress light signaling by 
      targeting photoreceptors and downstream transcription factors for ubiquitylation 
      and degradation. The activity of COP1 in plant cells correlates with its 
      cytoplasmic and nuclear partitioning according to dark or light conditions. In 
      addition, various signaling molecules have been shown to directly interact with 
      COP1 and modulate its activity. Recently, scientists have begun to probe the 
      function and regulation of COP1 in mammalian systems. Initial studies have 
      pointed at possible roles for mammalian COP1 in tumorigenesis and the stress 
      response through regulating the activities of p53 and c-Jun.
FAU - Yi, Chunling
AU  - Yi C
AD  - Department of Molecular, Cellular and Developmental Biology, Yale University, New 
      Haven, CT 06520-8104, USA.
FAU - Deng, Xing Wang
AU  - Deng XW
LA  - eng
GR  - GM47850/GM/NIGMS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Review
DEP - 20050929
PL  - England
TA  - Trends Cell Biol
JT  - Trends in cell biology
JID - 9200566
RN  - 0 (Arabidopsis Proteins)
RN  - 0 (Nuclear Proteins)
RN  - 0 (Proto-Oncogene Proteins c-jun)
RN  - 0 (Tumor Suppressor Protein p53)
RN  - EC 2.3.2.27 (AT2G32950 protein, Arabidopsis)
RN  - EC 2.3.2.27 (COP1 protein, human)
RN  - EC 2.3.2.27 (COP1 protein, mouse)
RN  - EC 2.3.2.27 (Ubiquitin-Protein Ligases)
SB  - IM
MH  - Animals
MH  - Arabidopsis Proteins/*physiology
MH  - Humans
MH  - Models, Biological
MH  - Morphogenesis/physiology/radiation effects
MH  - Neoplasms/etiology
MH  - Nuclear Proteins/*physiology
MH  - Plant Development
MH  - Plants/radiation effects
MH  - Protein Transport/physiology
MH  - Proto-Oncogene Proteins c-jun/metabolism
MH  - Tumor Suppressor Protein p53/metabolism
MH  - Ubiquitin-Protein Ligases/*physiology
RF  - 66
EDAT- 2005/10/04 09:00
MHDA- 2006/02/28 09:00
CRDT- 2005/10/04 09:00
PHST- 2005/07/04 00:00 [received]
PHST- 2005/08/24 00:00 [revised]
PHST- 2005/09/20 00:00 [accepted]
PHST- 2005/10/04 09:00 [pubmed]
PHST- 2006/02/28 09:00 [medline]
PHST- 2005/10/04 09:00 [entrez]
AID - S0962-8924(05)00231-X [pii]
AID - 10.1016/j.tcb.2005.09.007 [doi]
PST - ppublish
SO  - Trends Cell Biol. 2005 Nov;15(11):618-25. doi: 10.1016/j.tcb.2005.09.007. Epub 
      2005 Sep 29.