PMID- 16199372
OWN - NLM
STAT- MEDLINE
DCOM- 20051031
LR  - 20191109
IS  - 1061-186X (Print)
IS  - 1026-7158 (Linking)
VI  - 13
IP  - 5
DP  - 2005 Jun
TI  - Targeting of mannosylated liposome incorporated benzyl derivative of Penicillium 
      nigricans derived compound MT81 to reticuloendothelial systems for the treatment 
      of visceral leishmaniasis.
PG  - 285-93
AB  - The antileishmanial property of a Benzyl derivative of a new antibiotic MT81 
      (Bz2MT81), isolated and purified from a fungal strain of Penicillium nigricans 
      NRRL 917 was tested in free, liposome intercalated and mannose coated liposome 
      intercalated forms in vivo against visceral leishmaniasis in hamsters. Mannose 
      grafted liposome intercalated Bz2MT81 eliminated intracellular amastigotes of 
      Leishmania donovani within splenic macrophages more efficiently than the liposome 
      intercalated Bz2MT81 or free Bz2MT81. At a dose equivalent to 7.5 microg/Kg body 
      weight when injected subcutaneously (s.c) in mannose grafted liposome 
      intercalated form for 15 days in an interval of three days, the splenic parasitic 
      load decreased to the extent of 79.1% of the total parasite present in infected 
      control animals. Whereas, an identical amount (7.5 mug/Kg body weight) of Bz2MT81 
      in free or liposome intercalated form was found less effective in controlling the 
      parasite in spleen (in free Bz2MT81 form, suppression of parasitic load is 49.8% 
      and in liposome intercalated form, it is 55.1%). Both mannosylated liposomes and 
      Bz2MT81 were noted non-toxic to the host peritoneal macrophages. Histological 
      examinations of spleen and liver, kidney function tests (SGPT, alkaline 
      phosphatase, creatinine and urea in blood plasma) showed that the toxicity of 
      Bz2MT81 was reduced up to normal level when mannose grafted liposomal Bz2MT81 
      were administered.
FAU - Mitra, Maitreyi
AU  - Mitra M
AD  - Jadavpur University, Department of Pharmaceutical Technology, Kolkata, 700 032, 
      India.
FAU - Mandal, Ardhendu K
AU  - Mandal AK
FAU - Chatterjee, Tapan Kumar
AU  - Chatterjee TK
FAU - Das, Nirmalendu
AU  - Das N
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Drug Target
JT  - Journal of drug targeting
JID - 9312476
RN  - 0 (Anthraquinones)
RN  - 0 (Antiprotozoal Agents)
RN  - 0 (Benzyl Compounds)
RN  - 0 (Drug Carriers)
RN  - 0 (Excipients)
RN  - 0 (Fluoresceins)
RN  - 0 (Fluorescent Dyes)
RN  - 0 (Intercalating Agents)
RN  - 0 (Liposomes)
RN  - 11028-71-0 (Concanavalin A)
RN  - 3301-79-9 (6-carboxyfluorescein)
RN  - 82197-56-6 (MT81 mycotoxin)
RN  - 8T3HQG2ZC4 (Trinitrobenzenesulfonic Acid)
RN  - I2ZWO3LS3M (Trypan Blue)
RN  - PHA4727WTP (Mannose)
SB  - IM
MH  - Animals
MH  - Anthraquinones/*administration & dosage/pharmacokinetics/*therapeutic use
MH  - Antiprotozoal Agents/*administration & dosage/pharmacokinetics/*therapeutic use
MH  - Benzyl Compounds/*administration & dosage/pharmacokinetics/therapeutic use
MH  - Concanavalin A/pharmacology
MH  - Cricetinae
MH  - Drug Carriers
MH  - *Drug Delivery Systems
MH  - Excipients
MH  - Fluoresceins
MH  - Fluorescent Dyes
MH  - Intercalating Agents/pharmacology
MH  - Kidney Function Tests
MH  - Leishmaniasis, Visceral/*drug therapy/parasitology
MH  - Liposomes/*chemistry
MH  - Liver Function Tests
MH  - Macrophages/drug effects
MH  - Mannose/*chemistry
MH  - Mesocricetus
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Mononuclear Phagocyte System/*drug effects
MH  - Particle Size
MH  - Penicillium/*chemistry
MH  - Trinitrobenzenesulfonic Acid/pharmacology
MH  - Trypan Blue
EDAT- 2005/10/04 09:00
MHDA- 2005/11/01 09:00
CRDT- 2005/10/04 09:00
PHST- 2005/10/04 09:00 [pubmed]
PHST- 2005/11/01 09:00 [medline]
PHST- 2005/10/04 09:00 [entrez]
AID - X66440285953370U [pii]
AID - 10.1080/10611860500233306 [doi]
PST - ppublish
SO  - J Drug Target. 2005 Jun;13(5):285-93. doi: 10.1080/10611860500233306.