PMID- 16199515
OWN - NLM
STAT- MEDLINE
DCOM- 20060420
LR  - 20221207
IS  - 0027-8424 (Print)
IS  - 1091-6490 (Electronic)
IS  - 0027-8424 (Linking)
VI  - 102
IP  - 41
DP  - 2005 Oct 11
TI  - Retinoid X receptor ablation in adult mouse keratinocytes generates an atopic 
      dermatitis triggered by thymic stromal lymphopoietin.
PG  - 14795-800
AB  - To investigate the role of retinoid X receptors (RXRs) in epidermal homeostasis, 
      we generated RXRalphabeta(ep-/-) somatic mutants in which both RXRalpha and 
      RXRbeta are selectively ablated in epidermal keratinocytes of adult mice. These 
      mice develop a chronic dermatitis mimicking that observed in atopic dermatitis 
      (AD) patients. In addition, they exhibit immunological abnormalities including 
      elevated serum levels of IgE and IgG, associated with blood and tissue 
      eosinophilia, indicating that keratinocyte-selective ablation of RXRs also 
      generates a systemic syndrome similar to that found in AD patients. Furthermore, 
      the profile of increased expression of cytokines and chemokines in skin of 
      keratinocyte-selective RXRalphabeta-ablated mutants was typical of a T helper 
      2-type inflammation, known to be crucially involved in human AD pathogenesis. 
      Finally, we demonstrate that thymic stromal lymphopoietin, whose expression is 
      rapidly and strongly induced in RXRalphabeta-ablated keratinocytes, plays a key 
      role in initiating the skin and systemic AD-like pathologies.
FAU - Li, Mei
AU  - Li M
AD  - Institut de Genetique et de Biologie Moleculaire et Cellulaire (IGBMC), Institut 
      Clinique de la Souris (ICS), College de France, BP10142, 1 Rue Laurent Fries, 
      Illkirch 67404, CU de Strasbourg, France.
FAU - Messaddeq, Nadia
AU  - Messaddeq N
FAU - Teletin, Marius
AU  - Teletin M
FAU - Pasquali, Jean-Louis
AU  - Pasquali JL
FAU - Metzger, Daniel
AU  - Metzger D
FAU - Chambon, Pierre
AU  - Chambon P
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20050930
PL  - United States
TA  - Proc Natl Acad Sci U S A
JT  - Proceedings of the National Academy of Sciences of the United States of America
JID - 7505876
RN  - 0 (Cytokines)
RN  - 0 (Immunoglobulin G)
RN  - 0 (Retinoid X Receptors)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - GT0IL38SP4 (Thymic Stromal Lymphopoietin)
RN  - 0 (TSLP protein, mouse)
SB  - IM
MH  - Animals
MH  - Cytokines/*metabolism
MH  - Dermatitis, Atopic/*genetics
MH  - Genotype
MH  - Immunoglobulin E/blood
MH  - Immunoglobulin G/blood
MH  - Immunohistochemistry
MH  - Keratinocytes/*metabolism
MH  - Mice
MH  - Mice, Knockout
MH  - Retinoid X Receptors/*genetics
MH  - Skin/metabolism/pathology
MH  - Thymic Stromal Lymphopoietin
PMC - PMC1253602
EDAT- 2005/10/04 09:00
MHDA- 2006/04/21 09:00
PMCR- 2006/04/11
CRDT- 2005/10/04 09:00
PHST- 2005/10/04 09:00 [pubmed]
PHST- 2006/04/21 09:00 [medline]
PHST- 2005/10/04 09:00 [entrez]
PHST- 2006/04/11 00:00 [pmc-release]
AID - 0507385102 [pii]
AID - 010214795 [pii]
AID - 10.1073/pnas.0507385102 [doi]
PST - ppublish
SO  - Proc Natl Acad Sci U S A. 2005 Oct 11;102(41):14795-800. doi: 
      10.1073/pnas.0507385102. Epub 2005 Sep 30.