PMID- 16199599
OWN - NLM
STAT- MEDLINE
DCOM- 20060131
LR  - 20181113
IS  - 0306-6800 (Print)
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 31
IP  - 10
DP  - 2005 Oct
TI  - Preimplantation HLA typing: having children to save our loved ones.
PG  - 582-6
AB  - Preimplantation tissue typing has been proposed as a method for creating a tissue 
      matched child that can serve as a haematopoietic stem cell donor to save its sick 
      sibling in need of a stem cell transplant. Despite recent promising results, many 
      people have expressed their disapproval of this method. This paper addresses the 
      main concerns of these critics: the risk of preimplantation genetic diagnosis 
      (PGD) for the child to be born; the intention to have a donor child; the limits 
      that should be placed on what may be done to the donor child, and whether the 
      intended recipient can be someone other than a sibling. The author will show that 
      these concerns do not constitute a sufficient ground to forbid people to use this 
      technique to save not only a sibling, but also any other loved one's life. 
      Finally, the author briefly deals with two alternative scenarios: the creation of 
      a human leukocyte antigen (HLA) matched child as an insurance policy, and the 
      banking of HLA matched embryos.
FAU - Devolder, K
AU  - Devolder K
AD  - Ghent University, Centre for Environmental Philosophy and Bioethics, Blandijnberg 
      2, B-9000 Gent, Belgium. katrien.devolder@Ugent.be
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Donor Selection/*ethics
MH  - Family
MH  - Female
MH  - HLA Antigens/*immunology
MH  - Hematopoietic Stem Cell Transplantation/*ethics
MH  - Histocompatibility Testing/*ethics/methods
MH  - Humans
MH  - Intention
MH  - Pregnancy
MH  - Preimplantation Diagnosis/ethics
MH  - Risk Factors
MH  - Tissue Banks/ethics
MH  - Tissue and Organ Harvesting/ethics/methods
PMC - PMC1734026
OID - KIE: 124122
OTO - KIE
OT  - Genetics and Reproduction
EDAT- 2005/10/04 09:00
MHDA- 2006/02/01 09:00
PMCR- 2008/10/01
CRDT- 2005/10/04 09:00
PHST- 2005/10/04 09:00 [pubmed]
PHST- 2006/02/01 09:00 [medline]
PHST- 2005/10/04 09:00 [entrez]
PHST- 2008/10/01 00:00 [pmc-release]
AID - 31/10/582 [pii]
AID - 10.1136/jme.2004.010348 [doi]
PST - ppublish
SO  - J Med Ethics. 2005 Oct;31(10):582-6. doi: 10.1136/jme.2004.010348.