PMID- 16201619
OWN - NLM
STAT- MEDLINE
DCOM- 20051212
LR  - 20190715
IS  - 0013-936X (Print)
IS  - 0013-936X (Linking)
VI  - 39
IP  - 18
DP  - 2005 Sep 15
TI  - Tissue distribution of perfluorinated chemicals in harbor seals (Phoca vitulina) 
      from the Dutch Wadden Sea.
PG  - 6978-84
AB  - Perfluorinated acids (PFAs) are today widely distributed in the environment, even 
      in remote arctic areas. Recently, perfluorooctane sulfonate (PFOS) has been 
      identified in marine mammals all over the world, but information on the 
      compound-specific tissue distribution remains scarce. Furthermore, although 
      longer perfluorinated carboxylic acids (PFCAs) are used in industry and were 
      shown to cause severe toxic effects, still little is known on potential sources 
      or their widespread distribution. In this study, we report for the first time on 
      levels of longer chain PFCAs, together with some short chain PFAs, 
      perfluorobutane sulfonate (PFBS) and perfluorobutanoate (PFBA), in liver, kidney, 
      blubber, muscle, and spleen tissues of harbor seals (Phoca vitulina) from the 
      Dutch Wadden Sea. PFOS was the predominant compound in all seal samples measured 
      (ranging from 89 to 2724 ng/g wet weight); however, large variations between 
      tissues were monitored. Although these are preliminary results, it is, to our 
      knowledge, the first time that PFBS could be found at detectable concentrations 
      (2.3 +/- 0.7 ng/g w wt) in environmental samples. PFBS was only detected in 
      spleen tissue. PFCA levels were much lower than PFOS concentrations. The dominant 
      PFCA in all tissues was PFNA (perfluorononanoic acid), and concentrations 
      generally decreased in tissues for all other PFCA homologues with increasing 
      chain length. No clear relationship between PFOS levels in liver and kidney was 
      observed. Furthermore, hepatic PFDA (perfluorodecanoic acid) levels increased 
      with increasing body length, but in kidney tissue, PFDA levels showed an inverse 
      relationship with increasing body length. These data suggest large differences in 
      tissue distribution and accumulation patterns of perfluorinated compounds in 
      marine organisms.
FAU - Van de Vijver, Kristin Inneke
AU  - Van de Vijver KI
AD  - Department of Biology, University of Antwerp, Groenenborgerlaan 171, 2020 
      Antwerpen, Belgium. inneke.vandevijver@ua.ac.be
FAU - Hoff, Philippe
AU  - Hoff P
FAU - Das, Krishna
AU  - Das K
FAU - Brasseur, Sophie
AU  - Brasseur S
FAU - Van Dongen, Walter
AU  - Van Dongen W
FAU - Esmans, Eddy
AU  - Esmans E
FAU - Reijnders, Peter
AU  - Reijnders P
FAU - Blust, Ronny
AU  - Blust R
FAU - De Coen, Wim
AU  - De Coen W
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Environ Sci Technol
JT  - Environmental science & technology
JID - 0213155
RN  - 0 (Alkanesulfonic Acids)
RN  - 0 (Caprylates)
RN  - 0 (Carboxylic Acids)
RN  - 0 (Environmental Pollutants)
RN  - 0 (Fluorocarbons)
RN  - 0 (Sulfonic Acids)
RN  - 0 (Water Pollutants, Chemical)
RN  - 947VD76D3L (perfluorooctanoic acid)
RN  - 9H2MAI21CL (perfluorooctane sulfonic acid)
RN  - SE4TWR0K2C (perfluorobutane)
SB  - IM
MH  - Alkanesulfonic Acids/*analysis
MH  - Animals
MH  - Body Size
MH  - Caniformia
MH  - Caprylates/*analysis
MH  - Carboxylic Acids/analysis
MH  - Chromatography, Liquid
MH  - Distemper/mortality
MH  - Distemper Virus, Phocine/metabolism
MH  - Environmental Monitoring
MH  - Environmental Pollutants/*analysis
MH  - Female
MH  - Fluorocarbons/*analysis
MH  - Kidney/pathology
MH  - Male
MH  - Mass Spectrometry
MH  - Sex Factors
MH  - Sulfonic Acids/analysis
MH  - Time Factors
MH  - Tissue Distribution
MH  - Water Pollutants, Chemical
EDAT- 2005/10/06 09:00
MHDA- 2005/12/15 09:00
CRDT- 2005/10/06 09:00
PHST- 2005/10/06 09:00 [pubmed]
PHST- 2005/12/15 09:00 [medline]
PHST- 2005/10/06 09:00 [entrez]
AID - 10.1021/es050942+ [doi]
PST - ppublish
SO  - Environ Sci Technol. 2005 Sep 15;39(18):6978-84. doi: 10.1021/es050942+.