PMID- 16204936
OWN - NLM
STAT- MEDLINE
DCOM- 20060207
LR  - 20220409
IS  - 0918-6158 (Print)
IS  - 0918-6158 (Linking)
VI  - 28
IP  - 10
DP  - 2005 Oct
TI  - Inhibitory effects of Houttuynia cordata water extracts on anaphylactic reaction 
      and mast cell activation.
PG  - 1864-8
AB  - The present study was investigated the effect of Houttuynia cordata THUNB water 
      extract (HCWE) on mast cell-mediated anaphylactic reactions. The mast 
      cell-mediated anaphylactic reaction is involved in many allergic diseases such as 
      asthma and allergic rhinitis. HCWE has been used as a traditional medicine in 
      Korea and is known to have an antioxidant and anti-cancer activities. However, 
      its specific effect of mast cell-mediated anaphylactic reactions is still 
      unknown. We examined whether HCWE could inhibit compound 48/80-induced systemic 
      anaphylaxis, IgE-mediated passive cutaneous anaphylaxis (PCA), and mast cell 
      activation. The oral administration of HCWE inhibited compound 48/80-induced 
      systemic anaphylaxis in mice. HCWE also inhibited the local allergic reaction, 
      PCA, activated by anti-dinitrophenyl (DNP) IgE antibody in rats. HCWE reduced the 
      compound 48/80-induced mast cell degranulation and colchicine-induced deformation 
      of rat peritoneal mast cells (RPMC). Moreover, HCWE dose-dependently inhibited 
      histamine release and calcium uptake of RPMC induced by compound 48/80 or 
      anti-DNP IgE. HCWE increased the level of intracellular cAMP and inhibited 
      significantly the compound 48/80-induced cAMP reduction in RPMC. These results 
      suggest that HCWE may be beneficial in the treatment of mast cell-mediated 
      anaphylactic responses.
FAU - Li, Guang Zhao
AU  - Li GZ
AD  - Department of Anatomy, Yanbian University Medical School; Yanji City, 133000, 
      China.
FAU - Chai, Ok Hee
AU  - Chai OH
FAU - Lee, Moo Sam
AU  - Lee MS
FAU - Han, Eui-Hyeog
AU  - Han EH
FAU - Kim, Hyoung Tae
AU  - Kim HT
FAU - Song, Chang Ho
AU  - Song CH
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Japan
TA  - Biol Pharm Bull
JT  - Biological & pharmaceutical bulletin
JID - 9311984
RN  - 0 (Drugs, Chinese Herbal)
RN  - 0 (Houttuynia cordata extract)
RN  - 4091-50-3 (p-Methoxy-N-methylphenethylamine)
RN  - E0399OZS9N (Cyclic AMP)
RN  - SY7Q814VUP (Calcium)
SB  - IM
MH  - Anaphylaxis/chemically induced/metabolism/*prevention & control
MH  - Animals
MH  - Calcium/metabolism
MH  - Cyclic AMP/metabolism
MH  - Drugs, Chinese Herbal/*pharmacology
MH  - Histamine Release
MH  - Houttuynia
MH  - Male
MH  - Mast Cells/*drug effects/metabolism
MH  - Mice
MH  - Mice, Inbred ICR
MH  - p-Methoxy-N-methylphenethylamine/pharmacology
EDAT- 2005/10/06 09:00
MHDA- 2006/02/08 09:00
CRDT- 2005/10/06 09:00
PHST- 2005/10/06 09:00 [pubmed]
PHST- 2006/02/08 09:00 [medline]
PHST- 2005/10/06 09:00 [entrez]
AID - JST.JSTAGE/bpb/28.1864 [pii]
AID - 10.1248/bpb.28.1864 [doi]
PST - ppublish
SO  - Biol Pharm Bull. 2005 Oct;28(10):1864-8. doi: 10.1248/bpb.28.1864.