PMID- 16205778
OWN - NLM
STAT- MEDLINE
DCOM- 20060905
LR  - 20180309
IS  - 0893-133X (Print)
IS  - 0893-133X (Linking)
VI  - 31
IP  - 7
DP  - 2006 Jul
TI  - Cocaine self-administration reduces excitatory responses in the mouse nucleus 
      accumbens shell.
PG  - 1444-51
AB  - Drugs of abuse affect behavior by altering neuronal communication within the 
      brain. Previous research examining the effects of intraperitoneally administered 
      cocaine has revealed that cocaine alters excitatory glutamatergic signaling, both 
      directly through regulation of synaptic function, and indirectly through 
      regulation of cellular excitability in areas of the drug reward circuitry such as 
      the nucleus accumbens (NAcc) and ventral tegmental area. We have now extended 
      these findings by testing the hypothesis that self-administration of cocaine 
      might elicit similar alterations in excitatory signaling in the NAcc shell. We 
      observed that cocaine self-administration reduces synaptically evoked excitatory 
      responses recorded extracellularly in the NAcc shell compared to saline 
      self-administration. This alteration was not accompanied by alterations in paired 
      pulse ratio of synaptically evoked responses or in potentiation of these 
      responses by application of the adenylyl cyclase activator forskolin. This 
      reduction in glutamatergic signaling may be one mechanism by which cocaine exerts 
      its long-term behavioral effects.
FAU - Schramm-Sapyta, Nicole L
AU  - Schramm-Sapyta NL
AD  - Department of Molecular Physiology & Biophysics, Vanderbilt University School of 
      Medicine, Nashville, TN 37232-0615, USA.
FAU - Olsen, Christopher M
AU  - Olsen CM
FAU - Winder, Danny G
AU  - Winder DG
LA  - eng
GR  - T32 MH065215/MH/NIMH NIH HHS/United States
GR  - DA14151/DA/NIDA NIH HHS/United States
GR  - DA19112/DA/NIDA NIH HHS/United States
GR  - MH65215/MH/NIMH NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20051005
PL  - England
TA  - Neuropsychopharmacology
JT  - Neuropsychopharmacology : official publication of the American College of 
      Neuropsychopharmacology
JID - 8904907
RN  - 0 (Dopamine Uptake Inhibitors)
RN  - 0 (Excitatory Amino Acid Agonists)
RN  - 1F7A44V6OU (Colforsin)
RN  - 3KX376GY7L (Glutamic Acid)
RN  - I5Y540LHVR (Cocaine)
SB  - IM
MH  - Animals
MH  - Behavior, Animal/drug effects
MH  - Cocaine/*administration & dosage
MH  - Colforsin/pharmacology
MH  - Dopamine Uptake Inhibitors/*administration & dosage
MH  - Dose-Response Relationship, Drug
MH  - Drug Interactions
MH  - Evoked Potentials/drug effects/physiology/radiation effects
MH  - Excitatory Amino Acid Agonists/*pharmacology
MH  - Glutamic Acid/*pharmacology
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Nucleus Accumbens/*drug effects
MH  - Self Administration/methods
MH  - Time Factors
EDAT- 2005/10/06 09:00
MHDA- 2006/09/06 09:00
CRDT- 2005/10/06 09:00
PHST- 2005/10/06 09:00 [pubmed]
PHST- 2006/09/06 09:00 [medline]
PHST- 2005/10/06 09:00 [entrez]
AID - 1300918 [pii]
AID - 10.1038/sj.npp.1300918 [doi]
PST - ppublish
SO  - Neuropsychopharmacology. 2006 Jul;31(7):1444-51. doi: 10.1038/sj.npp.1300918. 
      Epub 2005 Oct 5.