PMID- 16205926
OWN - NLM
STAT- MEDLINE
DCOM- 20061113
LR  - 20181113
IS  - 0172-8172 (Print)
IS  - 0172-8172 (Linking)
VI  - 26
IP  - 7
DP  - 2006 May
TI  - Synovial proinflammatory cytokines and their correlation with matrix 
      metalloproteinase-3 expression in Behcet's disease. Does interleukin-1beta play a 
      major role in Behcet's synovitis?
PG  - 608-13
AB  - The objective of this study has been the well established fact that 
      proinflammatory cytokines and metalloproteinases play a crucial role in the 
      pathogenesis of chronic arthritis as well as the development of pannus, with the 
      eventual erosive changes. Among the proinflammatory cytokines, interleukin-18 
      (IL-18) has been shown to contribute to the pathogenesis of chronic synovitis by 
      increasing the secretion of interleukin-1beta (IL-1beta) and the tumor necrosis 
      factor-alpha (TNF-alpha) and also stimulating angiogenesis. The aim of this study 
      is to investigate the synovial IL-18, IL-1beta, TNF-alpha and matrix 
      metalloproteinase-3 (MMP-3) levels in patients with Behcet's disease (BD), and 
      compare them with the levels of patients with rheumatoid arthritis (RA) and 
      osteoarthritis (OA). 30 patients with BD, 20 with RA, and 20 with OA were 
      included in the study. The synovial levels of IL-18, IL-1beta, TNF-alpha and 
      MMP-3 were detected using the two-step sandwich ELISA method. The synovial IL-18, 
      TNF-alpha and MMP-3 levels were significantly higher in RA patients than patients 
      with BD (P=0.004, 0.019, 0.025, respectively) and with OA (P=0.004, 0.045, 0.032, 
      respectively). There were no differences, with respect to the cytokine levels, 
      when patients with BD were compared with those with OA. Patients with RA and BD 
      had higher IL-1beta levels than patients with OA (P=0.017, 0.013, respectively). 
      However, no such difference was found for IL-1beta between BD and RA patients. 
      Among patients with RA, positive correlations were found between TNF-alpha and 
      MMP-3 (r=0.683, P=0.001). Our results showed that MMP-3 and proinflammatory 
      cytokines, except IL-1beta, were expressed in relatively small quantities in 
      Behcet's synovitis. Detection of the lower levels of these cytokines and 
      metalloproteinases might explain the non-erosive character of Behcet's arthritis. 
      We suggest that IL-1beta may be involved in the pathogenesis of Behcet's 
      synovitis.
FAU - Pay, Salih
AU  - Pay S
AD  - Division of Rheumatology, Department of Medicine, Gulhane Military School of 
      Medicine, Etlik/Ankara 06018, Turkey. salihp@yahoo.com
FAU - Erdem, Hakan
AU  - Erdem H
FAU - Pekel, Aysel
AU  - Pekel A
FAU - Simsek, Ismail
AU  - Simsek I
FAU - Musabak, Ugur
AU  - Musabak U
FAU - Sengul, Ali
AU  - Sengul A
FAU - Dinc, Ayhan
AU  - Dinc A
LA  - eng
PT  - Journal Article
DEP - 20051005
PL  - Germany
TA  - Rheumatol Int
JT  - Rheumatology international
JID - 8206885
RN  - 0 (Interleukin-1)
RN  - 0 (Interleukin-18)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - EC 3.4.24.17 (Matrix Metalloproteinase 3)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Arthritis, Rheumatoid/etiology/immunology
MH  - Behcet Syndrome/enzymology/*etiology/immunology
MH  - Blood Sedimentation
MH  - Humans
MH  - Interleukin-1/analysis/*physiology
MH  - Interleukin-18/*analysis
MH  - Matrix Metalloproteinase 3/*analysis
MH  - Middle Aged
MH  - Osteoarthritis/etiology/immunology
MH  - Synovial Fluid/*chemistry
MH  - Tumor Necrosis Factor-alpha/*analysis
EDAT- 2005/10/06 09:00
MHDA- 2006/11/14 09:00
CRDT- 2005/10/06 09:00
PHST- 2004/10/19 00:00 [received]
PHST- 2005/07/28 00:00 [accepted]
PHST- 2005/10/06 09:00 [pubmed]
PHST- 2006/11/14 09:00 [medline]
PHST- 2005/10/06 09:00 [entrez]
AID - 10.1007/s00296-005-0040-0 [doi]
PST - ppublish
SO  - Rheumatol Int. 2006 May;26(7):608-13. doi: 10.1007/s00296-005-0040-0. Epub 2005 
      Oct 5.