PMID- 16210588
OWN - NLM
STAT- MEDLINE
DCOM- 20051213
LR  - 20201219
IS  - 0022-1767 (Print)
IS  - 0022-1767 (Linking)
VI  - 175
IP  - 8
DP  - 2005 Oct 15
TI  - The CD85J/leukocyte inhibitory receptor-1 distinguishes between conformed and 
      beta 2-microglobulin-free HLA-G molecules.
PG  - 4866-74
AB  - For a proper development of the placenta, maternal NK cells should not attack the 
      fetal extravillous cytotrophoblast cells. This inhibition of maternal NK cells is 
      partially mediated via the nonclassical MHC class I molecule HLA-G. Recently, we 
      demonstrated that HLA-G forms disulfide-linked high molecular complexes on the 
      surface of transfected cells. In the present study, we demonstrate that HLA-G 
      must associate with beta(2)m for its interaction with CD85J/leukocyte Ig-like 
      receptor-1 (LIR-1). Although HLA-G free H chain complexes are expressed on the 
      surface, they are not recognized and possibly interfere with CD85J/LIR-1 and 
      HLA-G interaction. The formation of these complexes on the cell surface might 
      represent a novel mechanism developed specifically by the HLA-G protein aimed to 
      control the efficiency of the CD85J/LIR-1-mediated inhibition. We also show that 
      endogenous HLA-G complexes are expressed on the cell surface. These findings 
      provide novel insights into the delicate interaction between extravillous 
      cytotrophoblast cells and NK cells in the decidua.
FAU - Gonen-Gross, Tsufit
AU  - Gonen-Gross T
AD  - The Lautenberg Center for General and Tumor Immunology, Hebrew 
      University-Hadassah Medical School, Jerusalem, Israel.
FAU - Achdout, Hagit
AU  - Achdout H
FAU - Arnon, Tal I
AU  - Arnon TI
FAU - Gazit, Roi
AU  - Gazit R
FAU - Stern, Noam
AU  - Stern N
FAU - Horejsi, Vaclav
AU  - Horejsi V
FAU - Goldman-Wohl, Debra
AU  - Goldman-Wohl D
FAU - Yagel, Simcha
AU  - Yagel S
FAU - Mandelboim, Ofer
AU  - Mandelboim O
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Immunol
JT  - Journal of immunology (Baltimore, Md. : 1950)
JID - 2985117R
RN  - 0 (Antigens, CD)
RN  - 0 (HLA Antigens)
RN  - 0 (HLA-G Antigens)
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 0 (LILRB1 protein, human)
RN  - 0 (Leukocyte Immunoglobulin-like Receptor B1)
RN  - 0 (Receptors, Immunologic)
RN  - 0 (beta 2-Microglobulin)
RN  - EC 3.4.22.2 (Papain)
SB  - IM
MH  - Antigens, CD/*physiology
MH  - Cell Line, Transformed
MH  - Cell Line, Tumor
MH  - HLA Antigens/*metabolism
MH  - HLA-G Antigens
MH  - Histocompatibility Antigens Class I/*metabolism
MH  - Humans
MH  - Killer Cells, Natural/physiology
MH  - Leukocyte Immunoglobulin-like Receptor B1
MH  - Papain
MH  - Receptors, Immunologic/*physiology
MH  - beta 2-Microglobulin/*metabolism
EDAT- 2005/10/08 09:00
MHDA- 2005/12/15 09:00
CRDT- 2005/10/08 09:00
PHST- 2005/10/08 09:00 [pubmed]
PHST- 2005/12/15 09:00 [medline]
PHST- 2005/10/08 09:00 [entrez]
AID - 175/8/4866 [pii]
AID - 10.4049/jimmunol.175.8.4866 [doi]
PST - ppublish
SO  - J Immunol. 2005 Oct 15;175(8):4866-74. doi: 10.4049/jimmunol.175.8.4866.