PMID- 16211271
OWN - NLM
STAT- MEDLINE
DCOM- 20051114
LR  - 20051007
IS  - 1021-335X (Print)
IS  - 1021-335X (Linking)
VI  - 14
IP  - 5
DP  - 2005 Nov
TI  - Dual FISH analysis of benign and malignant tumors of the salivary glands and 
      paranasal sinuses.
PG  - 1103-7
AB  - To date, the underlying genomic changes in benign and malignant tumors of 
      salivary-gland and paranasal-sinus origin are poorly understood. This is due in 
      part to the low incidence of these tumors and the enormous histological variety 
      of tumors within this head and neck region. We examined 58 of these tumors (14 
      adenoid cystic carcinomas, 9 adenocarcinomas, 5 cylindrical carcinomas, 11 
      pleomorphic adenomas, and 19 inverted papillomas) by dual fluorescence in situ 
      hybridization (FISH) with centromere-specific probes on six chromosomes (3, 7, 9, 
      11, 17, and 18) for numerical changes. In adenoid cystic carcinomas, monosomy of 
      chromosome 17 and polysomy of chromosomes 3, 9 and 11 were most frequently 
      encountered. In adenocarcinomas, monosomy of chromosome 17 and polysomy of 
      chromosomes 7 and 11 were most frequent. In cylindrical cell carcinomas, polysomy 
      of chromosomes 7, 9, 11 and 17 was present in the majority of tumors. Disomy is 
      rare, even in benign tumors. Polysomy is more frequent in malignant tumors than 
      in benign. Tetrasomy is found almost only in malignant tumors. In summary, the 
      occurrence of polysomy might reflect a step towards malignancy in tumors of the 
      salivary glands and paranasal mucosa. Polysomy of chromosome 11 could be defined 
      as typical for all investigated histological types of malignant tumor in this 
      region of the head and neck.
FAU - Gotte, Karl
AU  - Gotte K
AD  - Universitats-Hals-Nasen-Ohrenklinik, Universitatsklinikum Mannheim, D-68135 
      Mannheim, Germany. karl.goette@hno.ma.uni-heidelberg.de
FAU - Ganssmann, Stefan
AU  - Ganssmann S
FAU - Affolter, Annette
AU  - Affolter A
FAU - Schafer, Carsten
AU  - Schafer C
FAU - Riedel, Frank
AU  - Riedel F
FAU - Arens, Norbert
AU  - Arens N
FAU - Finger, Sonja
AU  - Finger S
FAU - Hormann, Karl
AU  - Hormann K
LA  - eng
PT  - Journal Article
PL  - Greece
TA  - Oncol Rep
JT  - Oncology reports
JID - 9422756
SB  - IM
MH  - Adenocarcinoma/*diagnosis/*genetics
MH  - Adenoma/*diagnosis/*genetics
MH  - Carcinoma, Adenoid Cystic/*diagnosis/*genetics
MH  - *Chromosome Aberrations
MH  - Diagnosis, Differential
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Papilloma/*diagnosis/*genetics
MH  - Salivary Gland Diseases/diagnosis/genetics
MH  - Salivary Gland Neoplasms/*diagnosis/*genetics
EDAT- 2005/10/08 09:00
MHDA- 2005/11/15 09:00
CRDT- 2005/10/08 09:00
PHST- 2005/10/08 09:00 [pubmed]
PHST- 2005/11/15 09:00 [medline]
PHST- 2005/10/08 09:00 [entrez]
PST - ppublish
SO  - Oncol Rep. 2005 Nov;14(5):1103-7.