PMID- 16213092
OWN - NLM
STAT- MEDLINE
DCOM- 20060706
LR  - 20220309
IS  - 0304-3959 (Print)
IS  - 0304-3959 (Linking)
VI  - 118
IP  - 1-2
DP  - 2005 Nov
TI  - Multilevel somatosensory system disinhibition in children with migraine.
PG  - 137-44
AB  - Although migraine is characterised by an abnormal cortical excitability level, 
      whether the central nervous system is hyper- or hypo-excitable in migraine still 
      remains an unsolved problem. The aim of our study was to compare the 
      somatosensory evoked potential (SEP) recovery cycle, a marker of the 
      somatosensory system's excitability, in a group of 15 children suffering from 
      migraine without aura (MO) (mean age 11.7+/-1.6 years, five males, 10 females) 
      and 10 control age-matched subjects (CS) (mean age 10.9+/-2.1 years, six males, 
      four females). We calculated the SEP's latency and amplitude modifications after 
      paired electrical stimuli at 5, 20 and 40 ms interstimulus intervals (ISIs), 
      comparing it with a single stimulus condition assumed as the baseline. In MO 
      patients, the amplitudes of the cervical N13 and of the cortical N20, P24 and N30 
      responses at 20 and 40 ms ISIs showed a higher recovery than in CS (two-way 
      ANOVA, P<0.05). Since, the SEP recovery cycle depends on the inhibitory 
      interneuron function, our findings suggest that a somatosensory system 
      disinhibition takes place in migraine. This is a generalized phenomenon, not 
      limited to the cerebral cortex, but concerning also the cervical grey matter. The 
      SEP recovery cycle reflects the intracellular concentration of Na(+), therefore, 
      the shortened recovery cycle in our MO patients suggests a high level of 
      intracellular Na(+) and a consequent depolarized resting membrane potential, 
      possibly due to an impaired Na(+) -K(+) ATPase function in migraine.
FAU - Valeriani, Massimiliano
AU  - Valeriani M
AD  - Headache Center, Divisione di Neurologia, Ospedale Pediatrico Bambino Gesu, 
      IRCCS, Piazza Sant'Onofrio 4, 00165 Rome, Italy. m.valeriani@tiscali.it
FAU - Rinalduzzi, Steno
AU  - Rinalduzzi S
FAU - Vigevano, Federico
AU  - Vigevano F
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20051004
PL  - United States
TA  - Pain
JT  - Pain
JID - 7508686
RN  - EC 7.2.2.13 (Sodium-Potassium-Exchanging ATPase)
SB  - IM
CIN - Pain. 2005 Nov;118(1-2):1-2. PMID: 16202523
MH  - Child
MH  - Electric Stimulation
MH  - Evoked Potentials, Somatosensory/*physiology
MH  - Female
MH  - Functional Laterality/physiology
MH  - Humans
MH  - Interneurons/metabolism/physiology
MH  - Male
MH  - Median Nerve/physiology
MH  - Membrane Potentials/physiology
MH  - Migraine without Aura/diagnosis/enzymology/*physiopathology
MH  - Neural Inhibition/physiology
MH  - Sodium-Potassium-Exchanging ATPase/metabolism/physiology
MH  - Somatosensory Cortex/*physiopathology
MH  - Spinal Cord/physiopathology
EDAT- 2005/10/11 09:00
MHDA- 2006/07/11 09:00
CRDT- 2005/10/11 09:00
PHST- 2005/03/30 00:00 [received]
PHST- 2005/07/19 00:00 [revised]
PHST- 2005/08/01 00:00 [accepted]
PHST- 2005/10/11 09:00 [pubmed]
PHST- 2006/07/11 09:00 [medline]
PHST- 2005/10/11 09:00 [entrez]
AID - S0304-3959(05)00463-X [pii]
AID - 10.1016/j.pain.2005.08.026 [doi]
PST - ppublish
SO  - Pain. 2005 Nov;118(1-2):137-44. doi: 10.1016/j.pain.2005.08.026. Epub 2005 Oct 4.