PMID- 16213155
OWN - NLM
STAT- MEDLINE
DCOM- 20060119
LR  - 20061115
IS  - 1043-4666 (Print)
IS  - 1043-4666 (Linking)
VI  - 32
IP  - 2
DP  - 2005 Oct 21
TI  - Contribution of the familial and genetic factors on monocyte chemoattractant 
      protein-1 variation in healthy human pedigrees.
PG  - 117-23
AB  - Monocyte chemoattractant protein-1 (MCP-1) is a chemokine whose circulating 
      levels have been detected in the lesions of several diseases such as pulmonary 
      fibrosis, rheumatoid arthritis and atherosclerosis. However, the factors involved 
      in the regulation of its production remain largely unknown. The main aim of the 
      present paper was to ascertain the contribution of the familial/genetic factors 
      on the production of MCP-1 in apparently healthy individuals. We also tested the 
      possible relationships between the plasma levels of MCP-1 and other cytokines 
      involved in bone metabolism (receptor activator NF-kB ligand (RANKL), 
      osteoprotegerin (OPG), interleukin-6, macrophage-colony stimulating factor, tumor 
      necrosis factor-alpha). Using ELISA assays the cytokine levels were measured in 
      570 apparently healthy individuals belonging to ethnically homogeneous Caucasian 
      families. We found that MCP-1 levels were significantly (P<0.01) correlated with 
      RANKL (in both sexes) and with OPG only in women. The study showed that adjusted 
      for potential covariates, 72% of the MCP-1 variance, was attributable to familial 
      effects. About 49% was due to potential genetic factors and the rest was 
      explained by common environmental sources shared by spouses within each family. 
      In conclusion, our data provide reliable evidence for the substantial role of 
      genetic factors in the determination of the phenotypic variability of MCP-1 
      plasma levels. The association between the osteoclastogenic cytokines and MCP-1 
      levels in healthy pedigrees is of special interest and might shed light on MCP-1 
      involvement in bone remodeling.
FAU - Pantsulaia, I
AU  - Pantsulaia I
AD  - Department of Anatomy and Anthropology, Human Population Biology Research Unit, 
      Sackler Faculty of Medicine, Tel Aviv University, Ramat Aviv, Tel Aviv 69978, 
      Israel.
FAU - Trofimov, S
AU  - Trofimov S
FAU - Kobyliansky, E
AU  - Kobyliansky E
FAU - Livshits, G
AU  - Livshits G
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20051005
PL  - England
TA  - Cytokine
JT  - Cytokine
JID - 9005353
RN  - 0 (Carrier Proteins)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Glycoproteins)
RN  - 0 (Interleukin-6)
RN  - 0 (Membrane Glycoproteins)
RN  - 0 (Osteoprotegerin)
RN  - 0 (RANK Ligand)
RN  - 0 (Receptor Activator of Nuclear Factor-kappa B)
RN  - 0 (Receptors, Cytoplasmic and Nuclear)
RN  - 0 (Receptors, Tumor Necrosis Factor)
RN  - 0 (TNFRSF11A protein, human)
RN  - 0 (TNFRSF11B protein, human)
RN  - 0 (TNFSF11 protein, human)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 81627-83-0 (Macrophage Colony-Stimulating Factor)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Bone Remodeling/genetics/physiology
MH  - Bone and Bones/metabolism
MH  - Carrier Proteins/blood
MH  - Chemokine CCL2/*blood/*genetics
MH  - Environment
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Glycoproteins/blood
MH  - Humans
MH  - Interleukin-6/blood
MH  - Macrophage Colony-Stimulating Factor/blood
MH  - Male
MH  - Membrane Glycoproteins/blood
MH  - Middle Aged
MH  - Osteoprotegerin
MH  - Pedigree
MH  - RANK Ligand
MH  - Receptor Activator of Nuclear Factor-kappa B
MH  - Receptors, Cytoplasmic and Nuclear/blood
MH  - Receptors, Tumor Necrosis Factor/blood
MH  - Tumor Necrosis Factor-alpha/analysis
EDAT- 2005/10/11 09:00
MHDA- 2006/01/20 09:00
CRDT- 2005/10/11 09:00
PHST- 2005/03/15 00:00 [received]
PHST- 2005/07/11 00:00 [revised]
PHST- 2005/08/24 00:00 [accepted]
PHST- 2005/10/11 09:00 [pubmed]
PHST- 2006/01/20 09:00 [medline]
PHST- 2005/10/11 09:00 [entrez]
AID - S1043-4666(05)00274-7 [pii]
AID - 10.1016/j.cyto.2005.08.006 [doi]
PST - ppublish
SO  - Cytokine. 2005 Oct 21;32(2):117-23. doi: 10.1016/j.cyto.2005.08.006. Epub 2005 
      Oct 5.