PMID- 16213359
OWN - NLM
STAT- MEDLINE
DCOM- 20051125
LR  - 20091119
IS  - 0165-4608 (Print)
IS  - 0165-4608 (Linking)
VI  - 162
IP  - 2
DP  - 2005 Oct 15
TI  - 3'CBFbeta deletion associated with inv(16) in acute myeloid leukemia.
PG  - 122-6
AB  - Recent reports have shown that concomitant submicroscopic deletions can occur in 
      association with chromosomal translocations/inversions in several leukemia 
      subtypes. Detectable by fluorescence in situ hybridization (FISH), these losses 
      of sequence include deletion of the 5' region of the ABL gene and the 3' region 
      of BCR in chronic myeloid leukemia (CML) and acute lymphoblastic leukemia (ALL), 
      as well as the 5' region of ETO in acute myeloid leukemia (AML) 
      French-American-British type M2 associated with t(8;21), 3'MLL in AML and ALL, 
      and 3' core-binding factor beta (CBFbeta) in AML associated with inv(16). While 
      it has been widely reported that submicroscopic deletions of the derivative 9 in 
      CML have an adverse prognostic impact, the clinical significance, if any, of 
      deletions associated with t(8;21), inv(16)/t(16;16), or MLL rearrangement is yet 
      to be determined. We analyzed a series of 39 patients diagnosed with AML who had 
      cytogenetically detectable inv(16)/t(16;16) by using a FISH probe for the CBFbeta 
      region to determine the incidence of the 3'CBFbeta deletion. Deletions were 
      detected in three patients (8%), all associated with inv(16), bringing the number 
      of cases reported so far to seven. The prognostic significance of this finding 
      remains unclear.
FAU - Kelly, Johanna
AU  - Kelly J
AD  - National Centre for Medical Genetics, Our Lady's Hospital for Sick Children, 
      Crumlin, Dublin 12, Republic of Ireland.
FAU - Foot, Nicola J
AU  - Foot NJ
FAU - Conneally, Eibhlin
AU  - Conneally E
FAU - Enright, Helen
AU  - Enright H
FAU - Humphreys, Mervyn
AU  - Humphreys M
FAU - Saunders, Karen
AU  - Saunders K
FAU - Neat, Michael J
AU  - Neat MJ
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Cancer Genet Cytogenet
JT  - Cancer genetics and cytogenetics
JID - 7909240
RN  - 0 (CBFB protein, human)
RN  - 0 (Core Binding Factor beta Subunit)
SB  - IM
MH  - Acute Disease
MH  - Adult
MH  - Aged
MH  - Chromosome Deletion
MH  - *Chromosome Inversion
MH  - *Chromosomes, Human, Pair 16
MH  - Core Binding Factor beta Subunit/*genetics
MH  - Female
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Leukemia, Myeloid/*genetics
MH  - Male
EDAT- 2005/10/11 09:00
MHDA- 2005/12/13 09:00
CRDT- 2005/10/11 09:00
PHST- 2004/10/18 00:00 [received]
PHST- 2005/02/21 00:00 [revised]
PHST- 2005/03/03 00:00 [accepted]
PHST- 2005/10/11 09:00 [pubmed]
PHST- 2005/12/13 09:00 [medline]
PHST- 2005/10/11 09:00 [entrez]
AID - S0165-4608(05)00136-6 [pii]
AID - 10.1016/j.cancergencyto.2005.03.001 [doi]
PST - ppublish
SO  - Cancer Genet Cytogenet. 2005 Oct 15;162(2):122-6. doi: 
      10.1016/j.cancergencyto.2005.03.001.