PMID- 16213368
OWN - NLM
STAT- MEDLINE
DCOM- 20051125
LR  - 20231213
IS  - 0165-4608 (Print)
IS  - 0165-4608 (Linking)
VI  - 162
IP  - 2
DP  - 2005 Oct 15
TI  - The presence of TEL/AML1 rearrangement and cryptic deletion of the TEL gene in 
      adult acute lymphoblastic leukemia (ALL).
PG  - 176-8
AB  - TEL/AML1 (also known as ETV6/RUNX1) rearrangement is the most frequent genetic 
      change in childhood B-acute lymphoblastic leukemia (ALL) and is associated with a 
      favorable prognosis. Its presence in adult ALL, however, has been questionable, 
      and any association between TEL/AML1 rearrangement and clinical prognosis is 
      unknown. To reveal the presence and incidence of the TEL/AML1 rearrangement in 
      adult ALL, we applied fluorescence in situ hybridization (FISH). We conducted 
      extra-signal, dual-color fluorescence in situ hybridization (ES-FISH) for 
      TEL/AML1 rearrangement on bone marrow cells from 74 adult ALL patients and 
      analyzed the survival time. We demonstrated the TEL/AML1 rearrangement in 2 
      patients (2.7%) among 74 patients with ALL. Of 74 adult ALL patients, 3 (4.0%) 
      showed deletion of the TEL gene without TEL/AML1 rearrangement. The mean survival 
      time of patients with TEL/AML1+ALL and patients with cryptic TEL deletion was 33 
      and 5 months, respectively, whereas the mean survival time of 53 TEL/AML1-ALL 
      patients was 16.7 months. TEL/AML1 rearrangement is not unique in childhood ALL, 
      and cryptic TEL deletion without TEL/AML1 rearrangement was more frequent than 
      the TEL/AML1 rearrangement in adult ALL. We recommend TEL/AML1 FISH in adult ALL 
      patients because conventional cytogenetic studies so far have yielded 
      uninformative results.
FAU - Lee, Dong Soon
AU  - Lee DS
AD  - Department of Laboratory Medicine and Cancer Research Institute, Seoul National 
      University College of Medicine, 28 Yongun-dong, Chongro-gu, Seoul 110-744, Korea. 
      soonlee@plaza.snu.ac.kr
FAU - Kim, Young Ree
AU  - Kim YR
FAU - Cho, Hyung Kyun
AU  - Cho HK
FAU - Lee, Chung Kee
AU  - Lee CK
FAU - Lee, Jee Hyung
AU  - Lee JH
FAU - Cho, Han Ik
AU  - Cho HI
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Cancer Genet Cytogenet
JT  - Cancer genetics and cytogenetics
JID - 7909240
RN  - 0 (Core Binding Factor Alpha 2 Subunit)
RN  - 0 (Oncogene Proteins, Fusion)
RN  - 0 (Proto-Oncogene Proteins c-ets)
RN  - 0 (Repressor Proteins)
RN  - 0 (TEL-AML1 fusion protein)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Core Binding Factor Alpha 2 Subunit/*genetics
MH  - Female
MH  - *Gene Deletion
MH  - *Gene Rearrangement
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Male
MH  - Middle Aged
MH  - Oncogene Proteins, Fusion/*genetics
MH  - Precursor Cell Lymphoblastic Leukemia-Lymphoma/*genetics
MH  - Proto-Oncogene Proteins c-ets/*genetics
MH  - Repressor Proteins/*genetics
MH  - ETS Translocation Variant 6 Protein
EDAT- 2005/10/11 09:00
MHDA- 2005/12/13 09:00
CRDT- 2005/10/11 09:00
PHST- 2004/08/04 00:00 [received]
PHST- 2005/02/15 00:00 [revised]
PHST- 2005/02/18 00:00 [accepted]
PHST- 2005/10/11 09:00 [pubmed]
PHST- 2005/12/13 09:00 [medline]
PHST- 2005/10/11 09:00 [entrez]
AID - S0165-4608(05)00121-4 [pii]
AID - 10.1016/j.cancergencyto.2005.02.020 [doi]
PST - ppublish
SO  - Cancer Genet Cytogenet. 2005 Oct 15;162(2):176-8. doi: 
      10.1016/j.cancergencyto.2005.02.020.