PMID- 16213737
OWN - NLM
STAT- MEDLINE
DCOM- 20060317
LR  - 20061115
IS  - 0968-0896 (Print)
IS  - 0968-0896 (Linking)
VI  - 14
IP  - 4
DP  - 2006 Feb 15
TI  - QSAR study on para-substituted aromatic sulfonamides as carbonic anhydrase II 
      inhibitors using topological information indices.
PG  - 1108-14
AB  - A linear quantitative structure-activity relationship has been developed for a 
      series of para-substituted aromatic sulfonamides by using topological index 
      methodologies. The compounds were studied for their carbonic anhydrase II (CAII) 
      inhibitory activity. A large series of topological indices were calculated and 
      the stepwise regression method was used to derive the most significant model. 
      Very good results were obtained using multi-parametric regressions and showed 
      that the information approach used in the present work is quite useful for 
      modeling carbonic anhydrase inhibition.
FAU - Melagraki, Georgia
AU  - Melagraki G
AD  - Laboratory of Organic Chemistry, School of Chemical Engineering, National 
      Technical University of Athens, Zografou Campus, Greece.
FAU - Afantitis, Antreas
AU  - Afantitis A
FAU - Sarimveis, Haralambos
AU  - Sarimveis H
FAU - Igglessi-Markopoulou, Olga
AU  - Igglessi-Markopoulou O
FAU - Supuran, Claudiu T
AU  - Supuran CT
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20051005
PL  - England
TA  - Bioorg Med Chem
JT  - Bioorganic & medicinal chemistry
JID - 9413298
RN  - 0 (Carbonic Anhydrase Inhibitors)
RN  - 0 (Sulfonamides)
RN  - EC 4.2.1.- (Carbonic Anhydrase II)
SB  - IM
MH  - Carbonic Anhydrase II/*antagonists & inhibitors/metabolism
MH  - Carbonic Anhydrase Inhibitors/*chemistry/*pharmacology
MH  - Molecular Structure
MH  - Quantitative Structure-Activity Relationship
MH  - Sulfonamides/*chemistry/*pharmacology
EDAT- 2005/10/11 09:00
MHDA- 2006/03/18 09:00
CRDT- 2005/10/11 09:00
PHST- 2005/06/08 00:00 [received]
PHST- 2005/09/05 00:00 [revised]
PHST- 2005/09/13 00:00 [accepted]
PHST- 2005/10/11 09:00 [pubmed]
PHST- 2006/03/18 09:00 [medline]
PHST- 2005/10/11 09:00 [entrez]
AID - S0968-0896(05)00897-7 [pii]
AID - 10.1016/j.bmc.2005.09.038 [doi]
PST - ppublish
SO  - Bioorg Med Chem. 2006 Feb 15;14(4):1108-14. doi: 10.1016/j.bmc.2005.09.038. Epub 
      2005 Oct 5.