PMID- 16214326
OWN - NLM
STAT- MEDLINE
DCOM- 20060406
LR  - 20061115
IS  - 0955-2863 (Print)
IS  - 0955-2863 (Linking)
VI  - 17
IP  - 3
DP  - 2006 Mar
TI  - Effects of caloric restriction and gender on rat serum paraoxonase 1 activity.
PG  - 197-203
AB  - Paraoxonase 1 (PON1) associates to specific high-density lipoproteins 
      (HDLs)--those containing apolipoprotein A-I (apoA-I) and apolipoprotein J 
      (apoJ)--and is largely responsible for their antiatherogenic properties. Caloric 
      restriction (CR) has been shown to reduce major atherosclerotic risk factors. The 
      aims of this work were to study PON1 activity response to CR (40% over 14 weeks) 
      and to elucidate whether there are adaptive differences related to gender. Serum 
      and liver paraoxonase and arylesterase activities, serum triglyceride, total and 
      HDL cholesterol concentrations, serum PON1, apoA-I and apoJ contents and liver 
      PON1 mRNA levels were measured. No effects of CR or gender were observed in 
      triglyceride, total cholesterol concentration and PON1 mRNA levels. HDL 
      cholesterol was higher in female rats than in male rats and increased with CR 
      only in the latter animals. Serum PON1 activities tended to be higher in female 
      rats and dropped with CR, with females showing the biggest decrease. Serum PON1 
      content was higher in female rats and decreased in both genders with CR, whereas 
      apoA-I and apoJ contents, which were higher in female rats too, decreased only in 
      the former animals, accounting for the high PON1 activity decrease observed in 
      these animals. In conclusion, the short-term CR-associated reduction of serum 
      PON1 activity and PON1, apoA-I and apoJ levels points toward a reduced stability 
      of HDL-PON1 complexes and/or HDL particle levels responsible for PON1 transport 
      and function in the blood. Moreover, the variations in PON1 activity and 
      apolipoprotein levels show gender-related differences that are indicative of a 
      different adaptive strategy of male and female rats when faced with a period of 
      food restriction.
FAU - Thomas-Moya, Elena
AU  - Thomas-Moya E
AD  - Grup de Metabolisme Energetic i Nutricio, Departament de Biologia Fonamental i 
      Ciencies de la Salut, Institut Universitari d'Investigacio en Ciencies de la 
      Salut (IUNICS), Universitat de les Illes Balears, Ed. Guillem Colom., Palma de 
      Mallorca, Spain.
FAU - Gianotti, Magdalena
AU  - Gianotti M
FAU - Llado, Isabel
AU  - Llado I
FAU - Proenza, Ana M
AU  - Proenza AM
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20050913
PL  - United States
TA  - J Nutr Biochem
JT  - The Journal of nutritional biochemistry
JID - 9010081
RN  - 0 (Apolipoprotein A-I)
RN  - 0 (Clusterin)
RN  - 0 (Lipids)
RN  - 0 (Proteins)
RN  - 0 (RNA, Messenger)
RN  - EC 3.1.8.1 (Aryldialkylphosphatase)
SB  - IM
MH  - Animals
MH  - Apolipoprotein A-I/blood
MH  - Aryldialkylphosphatase/*blood/genetics/metabolism
MH  - *Caloric Restriction
MH  - Clusterin/blood
MH  - Female
MH  - Food Deprivation
MH  - Lipids/blood
MH  - Liver/anatomy & histology/enzymology
MH  - Male
MH  - Microsomes, Liver/chemistry
MH  - Organ Size
MH  - Proteins/analysis
MH  - RNA, Messenger/analysis
MH  - Rats
MH  - *Sex Characteristics
EDAT- 2005/10/11 09:00
MHDA- 2006/04/07 09:00
CRDT- 2005/10/11 09:00
PHST- 2005/06/03 00:00 [received]
PHST- 2005/07/13 00:00 [revised]
PHST- 2005/07/20 00:00 [accepted]
PHST- 2005/10/11 09:00 [pubmed]
PHST- 2006/04/07 09:00 [medline]
PHST- 2005/10/11 09:00 [entrez]
AID - S0955-2863(05)00192-0 [pii]
AID - 10.1016/j.jnutbio.2005.07.004 [doi]
PST - ppublish
SO  - J Nutr Biochem. 2006 Mar;17(3):197-203. doi: 10.1016/j.jnutbio.2005.07.004. Epub 
      2005 Sep 13.