PMID- 16216619
OWN - NLM
STAT- MEDLINE
DCOM- 20060123
LR  - 20091111
IS  - 0022-0736 (Print)
IS  - 0022-0736 (Linking)
VI  - 38
IP  - 4
DP  - 2005 Oct
TI  - Prolonged recovery time in the left precordial leads reflects increased left 
      ventricular mass in the hypertensive patients.
PG  - 406-11
AB  - Hypertensive left ventricular hypertrophy (LVH) is considered to be a risk for 
      arrhythmogenicity, but the quantification of the changes in T-wave morphology, as 
      the reflection of repolarization abnormality, has not been fully established. The 
      purpose of this study was to quantify the T-wave changes in the hypertensive 
      patients and to investigate the relationship with the increased left ventricular 
      mass. Standard 12-lead electrocardiogram and echocardiogram were recorded in 90 
      hypertensive patients. Activation time (AT), activation recovery interval (ARI), 
      and recovery time (RT) were measured in the precordial lead and QT interval in 
      the 12 leads. To compare the left precordial T-wave changes among patients, 
      measurements of ARI and RT in the right precordial negative T wave were excluded. 
      Each parameter excluding AT was corrected with Bazett formula, and then the 
      dispersion was calculated. Left ventricular mass index was determined 
      echocardiographically to select non-LVH group (n=31) and LVH group (n=59). In 
      both groups, AT, ARI, and RT in the left precordial leads were larger compared 
      with those in the right precordial leads. Dispersion of AT was not different 
      between the 2 groups. However, the dispersion of ARI and RT in LVH group was 
      significantly greater than that in non-LVH group. There were correlations between 
      left ventricular mass index and the dispersion of RT (r=0.66, P<.001), ARI 
      (r=0.61, P<.001), and 12-lead QT (r=0.42, P<.001). In patients with LVH, 
      significant prolongation of RT in the left precordial leads was observed, 
      suggesting that this RT change resulted from the nonuniformity of epicardial 
      action potential duration.
FAU - Hara, Hideyuki
AU  - Hara H
AD  - Department of Internal Medicine/Cardiology, School of Medicine, Kitasato 
      University, Kanagawa 228-8555, Japan. hideyuki@med.kitasato-u.ac.jp
FAU - Niwano, Shinichi
AU  - Niwano S
FAU - Ikeda, Noriaki
AU  - Ikeda N
FAU - Izumi, Tohru
AU  - Izumi T
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
DEP - 20050725
PL  - United States
TA  - J Electrocardiol
JT  - Journal of electrocardiology
JID - 0153605
SB  - IM
MH  - Arrhythmias, Cardiac/*diagnosis/*etiology
MH  - *Electrocardiography
MH  - Female
MH  - Humans
MH  - Hypertension/*complications/*diagnosis
MH  - Hypertrophy, Left Ventricular/*diagnosis/*etiology
MH  - Male
MH  - Middle Aged
MH  - Prognosis
MH  - Recovery of Function
MH  - Risk Assessment/methods
MH  - Risk Factors
MH  - Time Factors
EDAT- 2005/10/12 09:00
MHDA- 2006/01/24 09:00
CRDT- 2005/10/12 09:00
PHST- 2005/03/14 00:00 [revised]
PHST- 2005/04/21 00:00 [accepted]
PHST- 2005/10/12 09:00 [pubmed]
PHST- 2006/01/24 09:00 [medline]
PHST- 2005/10/12 09:00 [entrez]
AID - S0022-0736(05)00071-3 [pii]
AID - 10.1016/j.jelectrocard.2005.04.001 [doi]
PST - ppublish
SO  - J Electrocardiol. 2005 Oct;38(4):406-11. doi: 10.1016/j.jelectrocard.2005.04.001. 
      Epub 2005 Jul 25.