PMID- 16216678
OWN - NLM
STAT- MEDLINE
DCOM- 20060117
LR  - 20061115
IS  - 0198-8859 (Print)
IS  - 0198-8859 (Linking)
VI  - 66
IP  - 8
DP  - 2005 Aug
TI  - MICA polymorphism in a population from north Morocco, Metalsa Berbers, using 
      sequence-based typing.
PG  - 931-6
AB  - The MICA gene encodes a family of nonclassical major histocompatibility complex 
      class I molecules. Data on MICA polymorphism in different populations are still 
      limited. In the present study, MICA allele frequencies (af) were assessed in 82 
      unrelated healthy individuals from a Moroccan Berber population named Metalsa 
      (ME) by means of sequence-based typing of exons 2, 3, 4, and 5. In consideration 
      of the linkage disequilibrium existing between MICA and human leukocyte antigen 
      (HLA) class I alleles, MICA/HLA-B, MICA/HLA-Cw, and MICA/HLA-A haplotype 
      frequencies (hf) were estimated. A wide allelic distribution including 16 
      different MICA alleles was found in ME. The most common MICA alleles were 
      MICA*00801 (af = 0.268), *004 (0.232), *00902 (0.140), *00901 (0.085), and *00901 
      (0.073). The most common MICA/HLA-B haplotypes were MICA*004-B*4403 and 
      MICA*009-B*50 (hf = 0.113 for both these haplotypes). Some known MICA and HLA-B 
      associations were confirmed in this population. Noteworthy was the high frequency 
      of MICA*009 (af = 0.226); the high frequency of B*50 found in ME (af = 0.114) 
      permitted us to evidence the associations of MICA*00902 with B*5001 (hf = 0.068) 
      or *5002 (hf = 0.045), whereas MICA*00901 was mainly associated with B*5101 (hf = 
      0.038), which corresponds to the previously described association 
      MICA*009/A6-HLA-B*51. This study extends the previous knowledge on MICA 
      polymorphism to a North African white population and may have implications for 
      disease associations and transplantation.
FAU - Piancatelli, Daniela
AU  - Piancatelli D
AD  - CNR Istituto per i Trapianti d'Organo e l'Immunocitologia, L'Aquila, Italy. 
      d.piancatelli@itoi.cnr.it
FAU - Del Beato, Tiziana
AU  - Del Beato T
FAU - Oumhani, Khadija
AU  - Oumhani K
FAU - El Aouad, Rajae
AU  - El Aouad R
FAU - Adorno, Domenico
AU  - Adorno D
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20050816
PL  - United States
TA  - Hum Immunol
JT  - Human immunology
JID - 8010936
RN  - 0 (HLA-A Antigens)
RN  - 0 (HLA-B Antigens)
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 0 (MHC class I-related chain A)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Alleles
MH  - Female
MH  - Gene Frequency
MH  - *Genetics, Population
MH  - HLA-A Antigens/genetics
MH  - HLA-B Antigens/genetics
MH  - Haplotypes
MH  - Histocompatibility Antigens Class I/*genetics
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Morocco
MH  - *Polymorphism, Genetic
MH  - Sequence Analysis, DNA
EDAT- 2005/10/12 09:00
MHDA- 2006/01/18 09:00
CRDT- 2005/10/12 09:00
PHST- 2005/02/23 00:00 [received]
PHST- 2005/10/12 09:00 [pubmed]
PHST- 2006/01/18 09:00 [medline]
PHST- 2005/10/12 09:00 [entrez]
AID - S0198-8859(05)00122-9 [pii]
AID - 10.1016/j.humimm.2005.06.008 [doi]
PST - ppublish
SO  - Hum Immunol. 2005 Aug;66(8):931-6. doi: 10.1016/j.humimm.2005.06.008. Epub 2005 
      Aug 16.