PMID- 16216696
OWN - NLM
STAT- MEDLINE
DCOM- 20051220
LR  - 20131121
IS  - 0361-9230 (Print)
IS  - 0361-9230 (Linking)
VI  - 67
IP  - 6
DP  - 2005 Nov 30
TI  - TRPV1 desensitisation and endogenous vanilloid involvement in the enhanced 
      analgesia induced by capsaicin in inflamed tissues.
PG  - 476-81
AB  - The intra-plantar acute administration of 10 microg of capsaicin to mice which 
      had received complete Freund's adjuvant (CFA) 1 week before inhibits the thermal 
      inflammatory hyperalgesia it induces and even produces a long-lasting analgesia 
      for at least 2 weeks. In this study, we show that the administration of capsaicin 
      (10 microg) also reduces the immediate licking behavior evoked by the 
      intra-plantar administration of a lower dose of capsaicin (0.1 microg), the 
      duration of this inhibitory effect being greater in CFA-inflamed mice (at least 2 
      weeks) than in non-inflamed animals (less than 4 days). Since this reduction of 
      capsaicin-induced licking behavior may be interpreted as a consequence of the 
      transient receptor potential vanilloid 1 receptor (TRPV1) unresponsiveness, we 
      conclude that the administration of 10 microg of capsaicin into inflamed tissues 
      can render the TRPV1 desensitised. We next explored whether endogenous vanilloids 
      released during inflammation contribute to maintain the analgesia triggered by 
      exogenous capsaicin. The acute administration of capsazepine (10 microg; 
      intra-plantarly (i.pl.)) abolished the analgesic effect induced by the injection 
      of capsaicin 1 week before in inflamed mice. From these results, it may be 
      proposed that the maintenance by endovanilloids of the TRPV1 desensitisation 
      induced by capsaicin could contribute to prolonging the analgesic effect induced 
      by this agonist in inflamed tissues.
FAU - Baamonde, Ana
AU  - Baamonde A
AD  - Laboratorio de Farmacologia, Facultad de Medicina, Instituto Universitario de 
      Oncologia del Principado de Asturias (IUOPA), Universidad de Oviedo, C/Julian 
      Claveria 6, 33006 Oviedo, Asturias, Spain. arbaiza@uniovi.es
FAU - Lastra, Ana
AU  - Lastra A
FAU - Juarez, Lucia
AU  - Juarez L
FAU - Hidalgo, Agustin
AU  - Hidalgo A
FAU - Menendez, Luis
AU  - Menendez L
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20050726
PL  - United States
TA  - Brain Res Bull
JT  - Brain research bulletin
JID - 7605818
RN  - 0 (Adjuvants, Immunologic)
RN  - 0 (Analgesics)
RN  - 0 (TRPV Cation Channels)
RN  - 0 (TRPV1 protein, mouse)
RN  - 9007-81-2 (Freund's Adjuvant)
RN  - LFW48MY844 (capsazepine)
RN  - S07O44R1ZM (Capsaicin)
SB  - IM
MH  - Adjuvants, Immunologic/pharmacology
MH  - Analgesics/pharmacology
MH  - Animals
MH  - Capsaicin/analogs & derivatives/*pharmacology
MH  - Freund's Adjuvant/pharmacology
MH  - Hyperalgesia/chemically induced/drug therapy/*physiopathology
MH  - Inflammation/chemically induced
MH  - Male
MH  - Mice
MH  - Pain/chemically induced/*physiopathology
MH  - Pain Measurement
MH  - TRPV Cation Channels/antagonists & inhibitors/*drug effects
EDAT- 2005/10/12 09:00
MHDA- 2005/12/21 09:00
CRDT- 2005/10/12 09:00
PHST- 2005/07/04 00:00 [received]
PHST- 2005/07/05 00:00 [accepted]
PHST- 2005/10/12 09:00 [pubmed]
PHST- 2005/12/21 09:00 [medline]
PHST- 2005/10/12 09:00 [entrez]
AID - S0361-9230(05)00261-3 [pii]
AID - 10.1016/j.brainresbull.2005.07.001 [doi]
PST - ppublish
SO  - Brain Res Bull. 2005 Nov 30;67(6):476-81. doi: 
      10.1016/j.brainresbull.2005.07.001. Epub 2005 Jul 26.