PMID- 16218464
OWN - NLM
STAT- MEDLINE
DCOM- 20051221
LR  - 20170214
IS  - 0961-2033 (Print)
IS  - 0961-2033 (Linking)
VI  - 14
IP  - 9
DP  - 2005
TI  - Idiopathic recurrent acute pericarditis: familial Mediterranean fever mutations 
      and disease evolution in a large cohort of Caucasian patients.
PG  - 670-4
AB  - Idiopathic recurrent acute pericarditis (IRAP) is suspected to be an autoimmune 
      phenomenon. We studied 46 consecutive patients. We looked for: 1) the occurrence 
      of new diagnoses of autoimmune diseases during our follow up; 2) HLA typing; and 
      3) the presence of the most frequent mutations linked to familial Mediterranean 
      fever (FMF gene or MEFV). HLA typing was done in 21 patients at loci B, DRB1, 
      DQA1 and DQB1. MEFV gene was looked in 23 patients using specific primers. During 
      the follow-up we made a new diagnosis of primary Sjogren's syndrome in four 
      patients (8.7%) and of rheumatoid arthritis in one patient (2.2%). HLA B14, 
      DRB1*01 and DQB1*0202 were significantly more prevalent, but we did not find a 
      typical HLA typing. MEFV gene was searched: exon 10 was checked by sequence and 
      the E148Q mutation by restriction site analysis. No mutations were found. In 
      conclusion, the prevalence of definite immunorheumatological diseases and the 
      absence of the mutations linked to FMF reinforce the notion that idiopathic acute 
      recurrent pericarditis is an autoimmune condition.
FAU - Brucato, A
AU  - Brucato A
AD  - Department of Medicine, Niguarda Hospital Milano, Italy. 
      antonio.brucato@ospedaleniguarda.it
FAU - Shinar, Y
AU  - Shinar Y
FAU - Brambilla, G
AU  - Brambilla G
FAU - Robbiolo, L
AU  - Robbiolo L
FAU - Ferrioli, G
AU  - Ferrioli G
FAU - Patrosso, M C
AU  - Patrosso MC
FAU - Zanni, D
AU  - Zanni D
FAU - Penco, S
AU  - Penco S
FAU - Boiani, E
AU  - Boiani E
FAU - Ghirardello, A
AU  - Ghirardello A
FAU - Caforio, A L P
AU  - Caforio AL
FAU - Bergantin, A
AU  - Bergantin A
FAU - Tombini, V
AU  - Tombini V
FAU - Moreo, A
AU  - Moreo A
FAU - Ashtamkar, L
AU  - Ashtamkar L
FAU - Doria, A
AU  - Doria A
FAU - Shoenfeld, Y
AU  - Shoenfeld Y
FAU - Livneh, A
AU  - Livneh A
LA  - eng
PT  - Journal Article
PL  - England
TA  - Lupus
JT  - Lupus
JID - 9204265
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Arthritis, Rheumatoid/diagnosis/genetics/immunology
MH  - Autoimmune Diseases/genetics
MH  - Biological Evolution
MH  - DNA Mutational Analysis
MH  - Familial Mediterranean Fever/complications/diagnosis/*genetics/immunology
MH  - Female
MH  - Genetic Predisposition to Disease
MH  - Genotype
MH  - HLA Antigens/genetics
MH  - Humans
MH  - Italy
MH  - Male
MH  - *Mutation
MH  - Pericarditis/etiology/*genetics/immunology
MH  - Sjogren's Syndrome/diagnosis/genetics/immunology
EDAT- 2005/10/13 09:00
MHDA- 2005/12/22 09:00
CRDT- 2005/10/13 09:00
PHST- 2005/10/13 09:00 [pubmed]
PHST- 2005/12/22 09:00 [medline]
PHST- 2005/10/13 09:00 [entrez]
AID - 10.1191/0961203305lu2197oa [doi]
PST - ppublish
SO  - Lupus. 2005;14(9):670-4. doi: 10.1191/0961203305lu2197oa.