PMID- 16218487
OWN - NLM
STAT- MEDLINE
DCOM- 20051221
LR  - 20170214
IS  - 0961-2033 (Print)
IS  - 0961-2033 (Linking)
VI  - 14
IP  - 9
DP  - 2005
TI  - Tumor necrosis factor-alpha, biologic agents and cardiovascular risk.
PG  - 780-4
AB  - The increased risk of premature cardiovascular disease (CVD) in rheumatoid 
      arthritis (RA) patients may depend on traditional risk factors but may also be 
      attributable to RA-specific risk factors such as disease-related dyslipidemia, or 
      cytokines such as tumor necrosis factor-alpha (TNF-alpha). TNF-alpha is a 
      proinflammatory cytokine that can produce widespread deleterious effects when 
      expressed in large amounts. It is produced in the heart by both cardiac myocytes 
      and resident macrophages under conditions of cardiac stress, and is thought to be 
      responsible for many of the untoward manifestations of cardiac disease. TNF-alpha 
      may play a role in the triggering and perpetuation of atherosclerosis. Treatment 
      with biologic agents directed against TNF-alpha has significant clinical benefits 
      in inflammatory diseases such as RA and may be able to reduce cardiovascular 
      risk. The disappointing results of the recent studies to antagonize TNF-alpha in 
      CVD may have various explanations. However, the effects of TNF-alpha blockers on 
      incident cases of congestive heart failure (CHF) in RA remains controversial. Due 
      to the lack of evidence of a beneficial effect of anti-TNF-alpha agents in 
      treatment of CHF, they should not be used to treat patients with New York Heart 
      Association (NYHA) class III or IV heart failure.
FAU - Sarzi-Puttini, P
AU  - Sarzi-Puttini P
AD  - Rheumatology Unit, L Sacco University Hospital, Milan, Italy. sarzi@tiscali.it
FAU - Atzeni, F
AU  - Atzeni F
FAU - Doria, A
AU  - Doria A
FAU - Iaccarino, L
AU  - Iaccarino L
FAU - Turiel, M
AU  - Turiel M
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Lupus
JT  - Lupus
JID - 9204265
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Animals
MH  - Arthritis, Rheumatoid/physiopathology
MH  - Atherosclerosis/immunology/physiopathology
MH  - Autoimmune Diseases/physiopathology
MH  - Cardiovascular Diseases/*immunology/physiopathology
MH  - Dyslipidemias/drug therapy/immunology
MH  - Heart Failure/drug therapy/immunology/physiopathology
MH  - Humans
MH  - Risk Factors
MH  - Tumor Necrosis Factor-alpha/antagonists & inhibitors/*metabolism
RF  - 33
EDAT- 2005/10/13 09:00
MHDA- 2005/12/22 09:00
CRDT- 2005/10/13 09:00
PHST- 2005/10/13 09:00 [pubmed]
PHST- 2005/12/22 09:00 [medline]
PHST- 2005/10/13 09:00 [entrez]
AID - 10.1191/0961203305lu2220oa [doi]
PST - ppublish
SO  - Lupus. 2005;14(9):780-4. doi: 10.1191/0961203305lu2220oa.