PMID- 1621873
OWN - NLM
STAT- MEDLINE
DCOM- 19920804
LR  - 20171213
IS  - 0002-9513 (Print)
IS  - 0002-9513 (Linking)
VI  - 262
IP  - 6 Pt 2
DP  - 1992 Jun
TI  - Absence of focal glomerulosclerosis in aging analbuminemic rats.
PG  - R947-54
AB  - The Nagase analbuminemic rat (NAR), a mutant of the Sprague-Dawley (SD) strain, 
      exhibits high levels of plasma cholesterol (Chol), thrombocytosis, and enhanced 
      platelet aggregability, which might promote glomerulosclerosis (GS). To determine 
      whether NAR are more susceptible than SD rats to aging GS, young (3-mo-old) and 
      aging (18-mo-old) SD rats and NAR were studied. In young NAR, glomerular pressure 
      and glomerular volume were lower, whereas total and high-density lipoprotein 
      plasma Chol levels were higher than in young SD rats. Aging SD rats developed 
      glomerular hypertension and hypertrophy. Less glomerular enlargement and 
      subnormal glomerular pressures were seen in aging NAR. Enhanced platelet 
      aggregation developed in aging SD rats, approaching the values seen in NAR. 
      Similarly elevated levels of low-density lipoprotein Chol were seen in additional 
      SD rats and NAR studied at 12 mo of age. Plasma triglyceride (TG) levels were 
      lower in NAR at this age. Only SD rats developed proteinuria and exhibited GS and 
      glomerular lipid deposits at 18 mo of age. Reduced glomerular wall stress due to 
      lower glomerular pressure and volume as well as lower TG levels may explain the 
      absence of GS in aging NAR despite plasma lipid and platelet abnormalities.
FAU - Fujihara, C K
AU  - Fujihara CK
AD  - Department of Internal Medicine, University of Sao Paulo School of Medicine, 
      Brazil.
FAU - Limongi, D M
AU  - Limongi DM
FAU - De Oliveira, H C
AU  - De Oliveira HC
FAU - Zatz, R
AU  - Zatz R
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Am J Physiol
JT  - The American journal of physiology
JID - 0370511
RN  - 0 (Serum Albumin)
RN  - 0 (Triglycerides)
RN  - 97C5T2UQ7J (Cholesterol)
SB  - IM
MH  - Aging/*physiology
MH  - Animals
MH  - Cholesterol/blood
MH  - Disease Susceptibility
MH  - Glomerular Filtration Rate
MH  - Glomerulosclerosis, Focal Segmental/*etiology/pathology
MH  - Hemodynamics
MH  - Kidney Glomerulus/pathology
MH  - Proteinuria/etiology
MH  - Rats
MH  - Rats, Mutant Strains
MH  - Serum Albumin/*analysis
MH  - Triglycerides/blood
EDAT- 1992/06/01 00:00
MHDA- 1992/06/01 00:01
CRDT- 1992/06/01 00:00
PHST- 1992/06/01 00:00 [pubmed]
PHST- 1992/06/01 00:01 [medline]
PHST- 1992/06/01 00:00 [entrez]
AID - 10.1152/ajpregu.1992.262.6.R947 [doi]
PST - ppublish
SO  - Am J Physiol. 1992 Jun;262(6 Pt 2):R947-54. doi: 10.1152/ajpregu.1992.262.6.R947.