PMID- 16218914
OWN - NLM
STAT- MEDLINE
DCOM- 20051223
LR  - 20211203
IS  - 0001-6314 (Print)
IS  - 0001-6314 (Linking)
VI  - 112
IP  - 5
DP  - 2005 Nov
TI  - Mediterranean and Amerindian MHC class II alleles are associated with multiple 
      sclerosis in Mexicans.
PG  - 317-22
AB  - OBJECTIVES: Human leukocyte antigen (HLA)-DRB1, DQA1, DQB1 allele typing was 
      performed in Mexicans Mestizos with multiple sclerosis (MS) to define the HLA 
      class II alleles associated with the disease in this population. METHODS: 
      Patients (n = 51) diagnosed according to the Poser criteria and a group of 173 
      unrelated healthy subjects were studied. PCR-SSOP and PCR-SSP were used for 
      genotyping. RESULTS: Fifty five percent of the patients were females. The mean 
      age at disease onset was 27 years. A relapsing-remitting disease was the most 
      frequent type of MS (67%). A significant association of DRB1*0403 (OR = 5.68) 
      with MS was shown. DRB1*0802 was also involved in susceptibility (OR = 2.41). An 
      excess of DRB1*0802 homozygotes was observed in patients (P = 0.005), this 
      genotype being in genetic equilibrium in controls. CONCLUSIONS: Two novel class 
      II associations are described in Mexicans with MS: DRB1*0403 and DRB1*0802. Both 
      alleles share with DRB1*1501, valine-86 and negatively charged amino acids, in 
      the DRB1-anchoring motif of pocket 4.
FAU - Alaez, C
AU  - Alaez C
AD  - Department of Immunology & Immunogenetics, Instituto de Diagnostico y Referencia 
      Epidemiologicos (InDRE), Secretary of Health, Mexico City, Mexico.
FAU - Corona, T
AU  - Corona T
FAU - Ruano, L
AU  - Ruano L
FAU - Flores, H
AU  - Flores H
FAU - Loyola, M
AU  - Loyola M
FAU - Gorodezky, C
AU  - Gorodezky C
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - Denmark
TA  - Acta Neurol Scand
JT  - Acta neurologica Scandinavica
JID - 0370336
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DQ alpha-Chains)
RN  - 0 (HLA-DQ beta-Chains)
RN  - 0 (HLA-DQA1 antigen)
RN  - 0 (HLA-DQB1 antigen)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DRB1 Chains)
RN  - 0 (Histocompatibility Antigens Class II)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - *Alleles
MH  - Ethnicity/*genetics
MH  - Female
MH  - Gene Frequency
MH  - Genetic Predisposition to Disease/genetics
MH  - Genotype
MH  - HLA-DQ Antigens/genetics
MH  - HLA-DQ alpha-Chains
MH  - HLA-DQ beta-Chains
MH  - HLA-DR Antigens/genetics
MH  - HLA-DRB1 Chains
MH  - Histocompatibility Antigens Class II/*genetics
MH  - Homozygote
MH  - Humans
MH  - Indians, Central American/*genetics
MH  - Male
MH  - Mediterranean Region/ethnology
MH  - Mexico
MH  - Middle Aged
MH  - Multiple Sclerosis, Chronic Progressive/*genetics
MH  - Multiple Sclerosis, Relapsing-Remitting/*genetics
EDAT- 2005/10/13 09:00
MHDA- 2005/12/24 09:00
CRDT- 2005/10/13 09:00
PHST- 2005/10/13 09:00 [pubmed]
PHST- 2005/12/24 09:00 [medline]
PHST- 2005/10/13 09:00 [entrez]
AID - ANE493 [pii]
AID - 10.1111/j.1600-0404.2005.00493.x [doi]
PST - ppublish
SO  - Acta Neurol Scand. 2005 Nov;112(5):317-22. doi: 10.1111/j.1600-0404.2005.00493.x.