PMID- 16219299
OWN - NLM
STAT- MEDLINE
DCOM- 20051220
LR  - 20131121
IS  - 0006-2952 (Print)
IS  - 0006-2952 (Linking)
VI  - 70
IP  - 11
DP  - 2005 Nov 25
TI  - Inhibition of store-operated calcium entry-mediated superoxide generation by 
      histamine trifluoromethyltoluide independent of histamine receptors.
PG  - 1613-22
AB  - Store-operated calcium entry (SOCE) plays an important role in shaping the Ca(2+) 
      response of various tissues and cell types. In this report, we show that 
      thapsigargin (TG)-induced SOCE was inhibited by the histamine receptor agonist, 
      histamine-trifluoromethyltoluide (HTMT), in U937 and HL-60 human promyelocytes. 
      Preincubation of HTMT resulted in a significant inhibition of subsequent 
      TG-induced Ca(2+) elevation without affecting Ca(2+) release from intracellular 
      stores. HTMT also inhibited TG-induced Ca(2+) current and Ba(2+)/Mn(2+) influx in 
      a concentration-dependent manner. In contrast with HTMT, other H1 histamine 
      receptor agonists, histamine, 2-methylhistamine and 2-thiazolylethylamine, did 
      not affect TG-induced SOCE. In addition, HTMT also attenuated TG-induced 
      cytosolic superoxide generation. Taken together, our data clearly suggest that 
      the anti-inflammatory effect of HTMT may occur through direct inhibition of SOCE.
FAU - Kim, Dong-Chan
AU  - Kim DC
AD  - Division of Molecular and Life Science, SBD-NCRC, Pohang University of Science 
      and Technology, Pohang 790-784, POSTECH, San 31, Hyoja Dong, South Korea.
FAU - Lee, So-Young
AU  - Lee SY
FAU - Jun, Dong-Jae
AU  - Jun DJ
FAU - Kim, Sun-Hee
AU  - Kim SH
FAU - Lee, Jong-Hee
AU  - Lee JH
FAU - Hur, Eun-Mi
AU  - Hur EM
FAU - Baek, Nam-In
AU  - Baek NI
FAU - Kim, Kyong-Tai
AU  - Kim KT
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20051010
PL  - England
TA  - Biochem Pharmacol
JT  - Biochemical pharmacology
JID - 0101032
RN  - 0 (Histamine Antagonists)
RN  - 0 (Receptors, Histamine)
RN  - 103827-16-3 (histamine trifluoromethyl-toluidide)
RN  - 11062-77-4 (Superoxides)
RN  - 820484N8I3 (Histamine)
RN  - SY7Q814VUP (Calcium)
SB  - IM
MH  - Calcium/*metabolism
MH  - HL-60 Cells
MH  - Histamine/*analogs & derivatives/pharmacology
MH  - Histamine Antagonists/*pharmacology
MH  - Humans
MH  - Receptors, Histamine/metabolism
MH  - Superoxides/*metabolism
MH  - U937 Cells
EDAT- 2005/10/13 09:00
MHDA- 2005/12/21 09:00
CRDT- 2005/10/13 09:00
PHST- 2005/08/15 00:00 [received]
PHST- 2005/09/02 00:00 [revised]
PHST- 2005/09/06 00:00 [accepted]
PHST- 2005/10/13 09:00 [pubmed]
PHST- 2005/12/21 09:00 [medline]
PHST- 2005/10/13 09:00 [entrez]
AID - S0006-2952(05)00587-3 [pii]
AID - 10.1016/j.bcp.2005.09.001 [doi]
PST - ppublish
SO  - Biochem Pharmacol. 2005 Nov 25;70(11):1613-22. doi: 10.1016/j.bcp.2005.09.001. 
      Epub 2005 Oct 10.