PMID- 16220004
OWN - NLM
STAT- MEDLINE
DCOM- 20051215
LR  - 20061115
IS  - 1018-2438 (Print)
IS  - 1018-2438 (Linking)
VI  - 138
IP  - 4
DP  - 2005 Dec
TI  - Dendritic cells in atopic dermatitis: expression of FcepsilonRI on two distinct 
      inflammation-associated subsets.
PG  - 278-90
AB  - BACKGROUND: Dendritic cells (DCs) represent a major portion within the infiltrate 
      of atopic dermatitis (AD) lesions. As antigen-presenting cells they have the 
      ability to regulate both the quantity and quality of T-cell responses and, thus, 
      are likely to play a key role in the pathogenesis of T-cell-dominated skin 
      diseases such as AD. Thus we sought to identify the DC repertoire occurring in AD 
      patients. METHODS: For this purpose, we phenotypically analyzed various defined 
      DC subsets of AD patients and healthy controls in skin biopsies and peripheral 
      blood by immunofluorescence staining. RESULTS: In AD lesions, two 
      inflammation-associated DC subsets with varying expression of costimulatory 
      molecules occurred besides epidermal Langerhans cells (LCs) and dermal myeloid 
      DCs (dmDCs) indigenously residing in normal skin: (1) 
      CD1a+/CD1c+/FcepsilonRI+/IgE+/CD207- myeloid DCs (mDCs) in the epidermis and 
      dermis and (2) CD123+/BDCA-2+/CD45RA+/CD68+ plasmacytoid DCs (pDCs) in the 
      dermis. In the peripheral blood of the patients, these cells exhibited an 
      immature phenotype. Interestingly, we found FcepsilonRI and cell-bound IgE to be 
      expressed not only on myeloid, but also on plasmacytoid DCs from both the skin 
      and peripheral blood of AD patients. CONCLUSIONS: It is tempting to speculate 
      that the disease-regulating role of inflammatory DCs in AD is influenced by both 
      FcepsilonRI occupancy and their degree of maturity.
CI  - Copyright (c) 2005 S. Karger AG, Basel.
FAU - Stary, Georg
AU  - Stary G
AD  - Department of Dermatology, Division of Immunology, Allergy and Infectious 
      Diseases, Medical University of Vienna, Vienna, Austria.
FAU - Bangert, Christine
AU  - Bangert C
FAU - Stingl, Georg
AU  - Stingl G
FAU - Kopp, Tamara
AU  - Kopp T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20051007
PL  - Switzerland
TA  - Int Arch Allergy Immunol
JT  - International archives of allergy and immunology
JID - 9211652
RN  - 0 (Receptors, IgE)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adult
MH  - Biopsy, Needle
MH  - Dendritic Cells/cytology/*immunology
MH  - Dermatitis, Atopic/blood/*immunology
MH  - Female
MH  - Flow Cytometry
MH  - Humans
MH  - Immunoglobulin E/immunology
MH  - Immunophenotyping
MH  - Male
MH  - Microscopy, Fluorescence
MH  - Receptors, IgE/*biosynthesis/immunology
EDAT- 2005/10/13 09:00
MHDA- 2005/12/16 09:00
CRDT- 2005/10/13 09:00
PHST- 2005/03/09 00:00 [received]
PHST- 2005/07/07 00:00 [accepted]
PHST- 2005/10/13 09:00 [pubmed]
PHST- 2005/12/16 09:00 [medline]
PHST- 2005/10/13 09:00 [entrez]
AID - 88865 [pii]
AID - 10.1159/000088865 [doi]
PST - ppublish
SO  - Int Arch Allergy Immunol. 2005 Dec;138(4):278-90. doi: 10.1159/000088865. Epub 
      2005 Oct 7.