PMID- 16220783
OWN - NLM
STAT- MEDLINE
DCOM- 20061127
LR  - 20131121
IS  - 0513-4870 (Print)
IS  - 0513-4870 (Linking)
VI  - 40
IP  - 5
DP  - 2005 May
TI  - [Intervention of cetirizine on monocyte chemoattractant protein-1 in cutaneous 
      inflammation].
PG  - 414-7
AB  - AIM: To study the intervention of cetirizine on monocyte chemoattractant 
      protein-1 (MCP-1) in different cutaneous inflammation models. METHODS: Histamine 
      and IFN-gamma stimulated dermal fibroblast cells and HaCaT cells to mimic 
      cutaneous inflammation. Expression of MCP-1 was assessed by means of RT-PCR and 
      ELISA. RESULTS: Compared with the control group of dermal fibroblast (DF) cells 
      and HaCaT cells, MCP-1 mRNA was significantly upregulated by histamine (10 
      micromol x L(-1)) and IFN-gamma (20 ng x mL(-1)). The protein secretions of MCP-1 
      were increased 3.5 fold and 8.4 fold in DF cells, respectively. The similar 
      tendency was observed in HaCaT cells. The enhancing effects of histamine and 
      IFN-gamma on MCP-1 protein production were significantly inhibited by cetirizine 
      (1 and 10 micromol x L(-1)) in DF and HaCaT cells. CONCLUSION: Cetirizine may 
      exert the anti-inflammatory effect of skin via inhibiting MCP-1 expression.
FAU - Song, Hong-jie
AU  - Song HJ
AD  - Department of Pharmacy, Changhai Hospital, the Second Military Medical 
      Univrersity, Shanghai 200433, China.
FAU - Hu, Jin-hong
AU  - Hu JH
FAU - Huang, Jin
AU  - Huang J
FAU - Xu, Yan-feng
AU  - Xu YF
FAU - Jing, Li
AU  - Jing L
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Yao Xue Xue Bao
JT  - Yao xue xue bao = Acta pharmaceutica Sinica
JID - 21710340R
RN  - 0 (CCL2 protein, human)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Histamine H1 Antagonists, Non-Sedating)
RN  - 0 (RNA, Messenger)
RN  - 820484N8I3 (Histamine)
RN  - 82115-62-6 (Interferon-gamma)
RN  - YO7261ME24 (Cetirizine)
SB  - IM
MH  - Cell Line
MH  - Cells, Cultured
MH  - Cetirizine/*pharmacology
MH  - Chemokine CCL2/*biosynthesis/genetics
MH  - Dermatitis/metabolism
MH  - Dermis/cytology
MH  - Fibroblasts/cytology/metabolism
MH  - Histamine/pharmacology
MH  - Histamine H1 Antagonists, Non-Sedating/*pharmacology
MH  - Humans
MH  - Interferon-gamma/pharmacology
MH  - Keratinocytes/cytology/metabolism
MH  - RNA, Messenger/biosynthesis/genetics
EDAT- 2005/10/14 09:00
MHDA- 2006/12/09 09:00
CRDT- 2005/10/14 09:00
PHST- 2005/10/14 09:00 [pubmed]
PHST- 2006/12/09 09:00 [medline]
PHST- 2005/10/14 09:00 [entrez]
PST - ppublish
SO  - Yao Xue Xue Bao. 2005 May;40(5):414-7.