PMID- 16221256
OWN - NLM
STAT- MEDLINE
DCOM- 20060330
LR  - 20071115
IS  - 0147-8389 (Print)
IS  - 0147-8389 (Linking)
VI  - 28
IP  - 10
DP  - 2005 Oct
TI  - Three year outcome of cardiac resynchronization therapy: a single center 
      evaluation.
PG  - 1013-7
AB  - AIMS: To evaluate the long-term clinical outcome and device performance of 
      cardiac resynchronization therapy in a consecutive sample of patients with 
      moderate to severe heart failure. METHODS AND RESULTS: Between 1998 and 2000, 
      forty consecutive patients with drug-refractory heart failure due to ischemic or 
      idiopathic dilated cardiomyopathy were selected for cardiac resynchronization 
      therapy (CRT). After successful implantation of the coronary sinus lead (n = 35, 
      88%), patients were followed every sixth month by New York Heart Association 
      (NYHA) functional class, the 6-minute walking test (6 walk), quality of life 
      (QoL, Minnesota), and pacemaker control. NYHA-class and 6 walk were significantly 
      improved after 6 months and continued to improve gradually until 36 months of 
      follow-up. The QoL improvement at 6 months was sustained over 3 years. After 3 
      years, the beta-blocker dose could be increased in 10/23 patients as compared to 
      baseline. Nine patients had to be re-operated. Coronary sinus lead thresholds 
      were stable over time. CONCLUSION: The clinical improvements by CRT are sustained 
      over 3 years of follow-up. In the setting of a University Medical Center, CRT can 
      be applied in clinical routine with excellent clinical outcome, acceptable 
      implantation success, and stable device performance over time.
FAU - Stahlberg, Marcus
AU  - Stahlberg M
AD  - Department of Cardiology, Karolinska Hospital, Stockholm, Sweden.
FAU - Braunschweig, Frieder
AU  - Braunschweig F
FAU - Gadler, Fredrik
AU  - Gadler F
FAU - Karlsson, Helena
AU  - Karlsson H
FAU - Linde, Cecilia
AU  - Linde C
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Pacing Clin Electrophysiol
JT  - Pacing and clinical electrophysiology : PACE
JID - 7803944
SB  - IM
MH  - Aged
MH  - Female
MH  - Heart Failure/*therapy
MH  - Humans
MH  - Male
MH  - *Pacemaker, Artificial
MH  - Time Factors
MH  - Treatment Outcome
EDAT- 2005/10/14 09:00
MHDA- 2006/03/31 09:00
CRDT- 2005/10/14 09:00
PHST- 2005/10/14 09:00 [pubmed]
PHST- 2006/03/31 09:00 [medline]
PHST- 2005/10/14 09:00 [entrez]
AID - PACE217 [pii]
AID - 10.1111/j.1540-8159.2005.00217.x [doi]
PST - ppublish
SO  - Pacing Clin Electrophysiol. 2005 Oct;28(10):1013-7. doi: 
      10.1111/j.1540-8159.2005.00217.x.