PMID- 16221290
OWN - NLM
STAT- MEDLINE
DCOM- 20060207
LR  - 20161124
IS  - 1085-9489 (Print)
IS  - 1085-9489 (Linking)
VI  - 10
IP  - 3
DP  - 2005 Sep
TI  - Tumor necrosis factor-alpha-converting enzyme is expressed in the inflamed 
      peripheral nervous system.
PG  - 311-8
AB  - Tumor necrosis factor-alpha (TNF-alpha) is considered to play a critical role in 
      the pathogenesis of immune-mediated inflammatory demyelinating disorders of the 
      peripheral nervous system (PNS). Processing of membrane-bound inactive 
      pro-TNF-alpha into the active soluble cytokine is mediated by a sheddase, the 
      so-called TNF-alpha-converting enzyme (TACE), a member of the A Disintegrin and 
      Metalloproteinase (ADAM) family. We explored the expression of TACE (ADAM-17) in 
      sciatic nerves from Lewis rats with experimental autoimmune neuritis (EAN), an 
      animal model of the Guillain-Barre syndrome (GBS), an immune-mediated 
      polyradiculoneuropathy. To extend our study to human disease, sural nerve 
      biopsies from GBS patients were investigated by immunohistochemistry. In EAN, T 
      lymphocytes could be defined as the cellular source of ADAM-17 with peak 
      expression levels at maximum clinical disease severity. Similarly, in human sural 
      nerves, ADAM-17-expressing T cells could be localized primarily within the epi- 
      and perineurium, whereas in control sections from patients with non-inflammatory 
      neuropathies, no expression could be depicted. Our findings indicate that ADAM-17 
      is upregulated during EAN and expressed in nerves of GBS patients and thus may 
      contribute to the pathogenesis of inflammatory demyelination of the PNS.
FAU - Kurz, Martin
AU  - Kurz M
AD  - Department of Neurology, Research Group for Clinical and Experimental 
      Neuroimmunology, Heinrich-Heine-University, Duesseldorf, Germany.
FAU - Pischel, Heidrun
AU  - Pischel H
FAU - Hartung, Hans-Peter
AU  - Hartung HP
FAU - Kieseier, Bernd C
AU  - Kieseier BC
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Peripher Nerv Syst
JT  - Journal of the peripheral nervous system : JPNS
JID - 9704532
RN  - 0 (Antigens, CD)
RN  - 0 (EDA protein, human)
RN  - 0 (Ectodysplasins)
RN  - 0 (Membrane Proteins)
RN  - 0 (Tumor Necrosis Factors)
RN  - 9007-81-2 (Freund's Adjuvant)
RN  - EC 3.4.24.- (ADAM Proteins)
RN  - EC 3.4.24.86 (ADAM17 Protein)
RN  - EC 3.4.24.86 (ADAM17 protein, human)
RN  - EC 3.4.24.86 (Adam17 protein, rat)
SB  - IM
MH  - ADAM Proteins/*metabolism
MH  - ADAM17 Protein
MH  - Animals
MH  - Antigens, CD/metabolism
MH  - Cell Count/methods
MH  - Disease Models, Animal
MH  - Ectodysplasins
MH  - Female
MH  - Freund's Adjuvant
MH  - Gene Expression Regulation, Enzymologic/drug effects/*physiology
MH  - Guillain-Barre Syndrome/metabolism/pathology
MH  - Humans
MH  - Immunohistochemistry/methods
MH  - Membrane Proteins/metabolism
MH  - Neuritis, Autoimmune, Experimental/chemically induced/complications/*metabolism
MH  - Rats
MH  - Rats, Inbred Lew
MH  - Sciatic Neuropathy/etiology/metabolism
MH  - Sural Nerve/metabolism
MH  - Time Factors
MH  - Tumor Necrosis Factors/metabolism
EDAT- 2005/10/14 09:00
MHDA- 2006/02/08 09:00
CRDT- 2005/10/14 09:00
PHST- 2005/10/14 09:00 [pubmed]
PHST- 2006/02/08 09:00 [medline]
PHST- 2005/10/14 09:00 [entrez]
AID - JNS10309 [pii]
AID - 10.1111/j.1085-9489.2005.10309.x [doi]
PST - ppublish
SO  - J Peripher Nerv Syst. 2005 Sep;10(3):311-8. doi: 
      10.1111/j.1085-9489.2005.10309.x.