PMID- 16222075
OWN - NLM
STAT- MEDLINE
DCOM- 20051202
LR  - 20131121
IS  - 0022-3077 (Print)
IS  - 0022-3077 (Linking)
VI  - 94
IP  - 5
DP  - 2005 Nov
TI  - Slow oscillatory firing: a major firing pattern of dopamine neurons in the 
      ventral tegmental area.
PG  - 3516-22
AB  - Using spectral analysis and in vivo single-unit recording in rats, the present 
      study revealed a pronounced slow oscillation (SO) in the firing activity of about 
      half the dopamine (DA) neurons recorded in the ventral tegmental area. DA neurons 
      in this group tended to fire repetitive spike clusters, making them appear to be 
      rhythmic bursting cells. However, only some of these burst-like events met the 
      traditional "80/160 ms" burst criteria entirely. The observation that the SO 
      could be found in nonbursting DA cells, occurred at frequencies different from 
      those of bursts, and persisted after bursts were digitally removed from spike 
      trains further supports the suggestion that the SO is different from the 
      traditionally defined bursting. Interspike intervals (ISIs) had been thought to 
      be bimodally distributed in bursting DA neurons. This study found that some 
      nonbursting DA cells also had a bimodal ISI distribution and a significant number 
      of bursting cells did not. In the majority of cells where less than half the 
      spikes occurred in bursts, a bimodal ISI distribution was highly predictive of 
      the presence of the SO. Results further showed that the generation of the SO 
      required forebrain inputs to DA neurons but not the adrenergic alpha1 receptor 
      activation responsible for psychostimulant-induced increases in the SO. Taken 
      together, these results suggest that the SO is distinct from the traditionally 
      defined bursting and represents a major firing pattern of DA neurons in the 
      ventral tegmental area.
FAU - Shi, Wei-Xing
AU  - Shi WX
AD  - Neuropsychopharmacological Research Unit, Yale University School of Medicine, 300 
      George St., Rm. 8300C, New Haven, CT 06511, USA. wei-xing.shi@yale.edu
LA  - eng
GR  - DA-12944/DA/NIDA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Neurophysiol
JT  - Journal of neurophysiology
JID - 0375404
RN  - VTD58H1Z2X (Dopamine)
SB  - IM
MH  - Action Potentials/*physiology
MH  - Animals
MH  - Biological Clocks/*physiology
MH  - Dopamine/*metabolism
MH  - Male
MH  - Neurons/*physiology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Synaptic Transmission/physiology
MH  - Ventral Tegmental Area/*physiology
EDAT- 2005/10/14 09:00
MHDA- 2005/12/13 09:00
CRDT- 2005/10/14 09:00
PHST- 2005/10/14 09:00 [pubmed]
PHST- 2005/12/13 09:00 [medline]
PHST- 2005/10/14 09:00 [entrez]
AID - 94/5/3516 [pii]
AID - 10.1152/jn.00317.2005 [doi]
PST - ppublish
SO  - J Neurophysiol. 2005 Nov;94(5):3516-22. doi: 10.1152/jn.00317.2005.