PMID- 16222734
OWN - NLM
STAT- MEDLINE
DCOM- 20060125
LR  - 20190430
IS  - 1007-9327 (Print)
IS  - 2219-2840 (Electronic)
IS  - 1007-9327 (Linking)
VI  - 11
IP  - 35
DP  - 2005 Sep 21
TI  - Hepatic fibrosis in biliary-obstructed rats is prevented by Ginkgo biloba 
      treatment.
PG  - 5444-9
AB  - AIM: To assess the antioxidant and antifibrotic effects of long-term Ginkgo 
      biloba administration on liver fibrosis induced by biliary obstruction in rats. 
      METHODS: Liver fibrosis was induced in male Wistar albino rats by bile duct 
      ligation and scission (BDL). Ginkgo biloba extract (EGb 761, 50 mg/kg.per d) or 
      saline was administered for 28 d. At the end of the treatment period, all rats 
      were killed. Serum aspartate aminotransferase (AST), alanine aminotransferase 
      (ALT), and lactate dehydrogenase (LDH) levels were determined to assess liver 
      functions and tissue damage, respectively. Tumor necrosis factor-alpha 
      (TNF-alpha) was also assayed in serum samples. Liver tissues were taken for 
      determination of the hepatic malondialdehyde (MDA) and glutathione (GSH) levels, 
      myeloperoxidase (MPO) activity and collagen content. Production of reactive 
      oxidants was monitored by chemiluminescence (CL) assay. Serum AST, ALT, LDH, and 
      TNF-alpha levels were elevated in the BDL group as compared to control group and 
      were significantly decreased by EGb treatment. RESULTS: Hepatic GSH level, 
      depressed by BDL, was elevated back to control level in EGb-treated BDL group. 
      Increase in tissue MDA level, MPO activity and collagen content due to BDL were 
      also attenuated by EGb treatment. Furthermore, luminol and lucigenin CL values in 
      BDL group increased dramatically compared to control and reduced by EGb 
      treatment. CONCLUSION: Our results suggest that Ginkgo biloba protects the liver 
      from oxidative damage following BDL in rats. This effect possibly involves the 
      inhibition of neutrophil infiltration and lipid peroxidation; thus, restoration 
      of oxidant and antioxidant status in the tissue.
FAU - Sener, Goksel
AU  - Sener G
AD  - Department of Pharmacology, School of Pharmacy, Marmara University, Tlbbiye Cad. 
      istanbul 34668, Turkey. gokselsener@hotmail.com
FAU - Kabasakal, Levent
AU  - Kabasakal L
FAU - Yuksel, Meral
AU  - Yuksel M
FAU - Gedik, Nursal
AU  - Gedik N
FAU - Alican, Ynci
AU  - Alican Y
LA  - eng
PT  - Journal Article
PL  - United States
TA  - World J Gastroenterol
JT  - World journal of gastroenterology
JID - 100883448
RN  - 0 (Antioxidants)
RN  - 0 (Plant Extracts)
RN  - 19FUJ2C58T (Ginkgo biloba extract)
SB  - IM
MH  - Animals
MH  - Antioxidants/pharmacology
MH  - Cholestasis/complications
MH  - Ginkgo biloba
MH  - Lipid Peroxidation/drug effects
MH  - Liver/drug effects/metabolism
MH  - Liver Cirrhosis/etiology/*prevention & control
MH  - Male
MH  - Phytotherapy
MH  - Plant Extracts/*pharmacology
MH  - Rats
MH  - Rats, Wistar
PMC - PMC4320351
EDAT- 2005/10/14 09:00
MHDA- 2006/01/26 09:00
PMCR- 2005/09/21
CRDT- 2005/10/14 09:00
PHST- 2005/10/14 09:00 [pubmed]
PHST- 2006/01/26 09:00 [medline]
PHST- 2005/10/14 09:00 [entrez]
PHST- 2005/09/21 00:00 [pmc-release]
AID - 10.3748/wjg.v11.i35.5444 [doi]
PST - ppublish
SO  - World J Gastroenterol. 2005 Sep 21;11(35):5444-9. doi: 10.3748/wjg.v11.i35.5444.